912545-86-9 Usage
Uses
Used in Pharmaceutical Research:
Smoothened agonist is used as a research tool for studying the Hedgehog signaling pathway in various cancers and brain diseases. Its ability to activate Smo protein function has been identified as a potential therapeutic target for the treatment of these conditions.
Used in Neuroscience Research:
Smoothened agonist is used as a sonic hedgehog (SHH) pathway agonist in neuroscience research to study its effects on mouse hippocampal cells. This helps researchers understand the role of the SHH pathway in brain function and the potential for developing treatments for neurological disorders.
Used in Developmental Biology:
In developmental biology, Smoothened agonist is used to study its effects on the mitochondrial network in zebrafish embryos. This research provides insights into the role of the SHH pathway in embryonic development and may contribute to the development of treatments for congenital disorders.
Used in Cell Biology:
Smoothened agonist is used in cell biology research to study its effects on murine embryonic fibroblasts. This helps researchers understand the role of the SHH pathway in cell growth, differentiation, and proliferation, which may have implications for the development of treatments for various diseases.
Biochem/physiol Actions
SAG is a potent and cell-permeable smoothened (Smo) agonist that activates Hedgehog pathway and counteracts Cyclopamine inhibition of Smo.
References
References/Citations
1) Chen?et al. (2002), Small molecule modulation of Smoothened activity; Proc. Natl. Acad. Sci. USA,?99?1407
Check Digit Verification of cas no
The CAS Registry Mumber 912545-86-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,1,2,5,4 and 5 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 912545-86:
(8*9)+(7*1)+(6*2)+(5*5)+(4*4)+(3*5)+(2*8)+(1*6)=169
169 % 10 = 9
So 912545-86-9 is a valid CAS Registry Number.
912545-86-9Relevant academic research and scientific papers
Potent agonists of the Hedgehog signaling pathway
Brunton, Shirley A.,Stibbard, John H.A.,Rubin, Lee L.,Guicherit, Oivin M.,Kruse, Lawrence I.,Price, Stephen,di Lucrezia, Raffaella,MacKinnon, Colin H.,Avery, Alaric,Park, Yvonne,Buxton, Danielle,Boyd, Edward A
scheme or table, p. 4308 - 4311 (2010/04/26)
A family of biaryl substituted 1,4-diaminocyclohexanamides of 3-chlorobenzothiophene-2-carboxylic acid is reported as picomolar modulators of Hedgehog protein function. SAR for the 1,4-diaminocyclohexane group is shown to be exquisitely sensitive to subst
