91259-90-4Relevant articles and documents
TRICYCLIC FUSED THIOPHENE DERIVATIVES AS JAK INHIBITORS
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Paragraph 0852; 0853, (2014/05/08)
The present invention provides tricyclic fused thiophene derivatives, as well as their compositions and methods of use, that modulate the activity of Janus kinase (JAK) and are useful in the treatment of diseases related to the activity of JAK including, for example, inflammatory disorders, autoimmune disorders, cancer, and other diseases.
BRIDGED MACROCYCLIC MODULE COMPOSITIONS
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Page/Page column 115, (2010/02/11)
This invention is related to the fields of organic chemistry and nanotechnology. In particular, it relates to materials and methods for the preparation of organic synthons and bridged macrocyclic module compounds. The bridged macrocyclic module compounds may be used to prepare macrocyclic compositions such as nanofilms, which may be useful for filtration.
Heterogeneous foldamers containing alpha, beta, and/or gamma-amino acids
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, (2008/06/13)
Disclosed are isolated, unnatural polypeptides containing cyclically-constrained β-amino acid residues and cyclically-constrained γ-amino acid residues. The compounds are unnatural and because they contain rotationally constrained residues that are not amenable to enzymatic degradation, the compounds are useful to probe protein-protein and other large molecule interactions.
Nanofilm and membrane compositions
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, (2008/06/13)
Nanofilms useful for filtration are prepared from oriented amphiphilic molecules and oriented macrocyclic modules. The amphiphilic species may be oriented on an interface or surface. The nanofilm may be prepared by depositing or attaching an oriented layer to a substrate. A nanofilm may also be prepared by coupling the oriented macrocyclic modules to provide a membrane.
Macrocyclic module compositions
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Page/Page column 29, (2008/06/13)
Macrocyclic module compositions are made from cyclic synthons. The macrocyclic module structures are prepared by stepwise or concerted schemes which couple synthons in a closed ring. The macrocyclic module structures may have a pore of nanometer dimensions.
Method for delivery of molecules to intracellular targets
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, (2008/06/13)
Disclosed are β-peptides and β-peptide conjugates that are capable of diffusing or otherwise being transported across the cell membranes of living cells. The β-peptides contain at least six β-amino acid residues, at leastsix of which are preferably β3-homoarginine residues. It has been found that when pharmacologically-active agents are conjugated to these types of β-peptides, the resulting conjugates (also disclosed herein) are also capable of diffusing or otherwise being transported across the cell membranes of living cells, including mammalian cells.
Efficient asymmetric synthesis of unnatural β-amino acids
Bolm,Schiffers,Dinter,Defrere,Gerlach,Raabe
, p. 1719 - 1730 (2007/10/03)
The simple and highly enantioselective methanolysis of cyclic meso-anhydrides mediated by cinchona alkaloids leads to a broad variety of dicarboxylic acid mono-methyl esters with up to 99% ee. From these products, unnatural N-protected β-amino esters can be obtained by means of Curtius degradation of the corresponding acyl azides. Subsequent cleavage of the protecting groups leads to the free β-amino acids in excellent yields. By enantiomer differentiating opening of racemic anhydrides, synthetically highly useful regioisomeric amino acid esters become readily available.
DIVERSIFIED SYNTHETIC APPROACHES TO THE CARBAPENEM ANTIBIOTICS BASED ON SYMMETRIZATION-ASYMMETRIZATION CONCEPT
Kurihara, Masa-aki,Kamiyama, Keiji,Kobayashi, Susumu,Ohno, Masaji
, p. 5831 - 5834 (2007/10/02)
cis-Fused bicyclic β-lactam compound 9, a key intermediate to cis-substituted carbapenem antibiotics, has been synthesized in optically pure form based on symmetrization-asymmetrization concept.
