912653-79-3Relevant academic research and scientific papers
Desymmetrization of cyclic 1,3-diketones via Ir-catalyzed hydrogenation: An efficient approach to cyclic hydroxy ketones with a chiral quaternary carbon
Gong, Quan,Wen, Jialin,Zhang, Xumu
, p. 6350 - 6353 (2019)
We herein report an efficient method to synthesize cyclic hydroxy ketones with a chiral quaternary center. Catalyzed by an Ir/f-ampha complex, cyclic α,α-disubstituted 1,3-diketones were hydrogenated, giving mono-reduced products with both high enantiosel
Chiral base mediated transformation of cyclic 1,3-diketones
Butler, Benjamin,Schultz, Thomas,Simpkins, Nigel S.
, p. 3634 - 3636 (2008/09/20)
Treatment of certain 1,3-diketones with a chiral lithium amide base results in the formation of a non-racemic lithium mono-enolate; these intermediates can be transformed directly into chiral hydroxyketone products by reduction with DIBAL-H in high yield and with selectivities of up to 99% ee. The Royal Society of Chemistry 2006.
