91272-25-2Relevant articles and documents
Easy and efficient copper-catalyzed synthesis of bicyclic pyrimidinones under mild conditions
Guo, Qi,Yang, Haijun,Liu, Hongxia,Jiang, Yuyang,Fu, Hua
experimental part, p. 2611 - 2616 (2010/11/24)
A simple and efficient copper-catalyzed method has been developed for synthesis of bicyclic pyrimidinones containing six-, seven-, eight-membered rings under mild conditions. The protocol uses readily available 2-bromocycloalk-1-enecarboxylic acids, amidines, and guanidines as the starting materials, copper-catalyzed cascade couplings provide the corresponding bicyclic pyrimidinones without addition of any ligand or additive, and the method is of economical and practical advantages. Georg Thieme Verlag Stuttgart New York.
