91272-26-3Relevant academic research and scientific papers
Microwave-assisted copper-powder-catalyzed synthesis of pyrimidinones from β-bromo α,β-unsaturated carboxylic acids and amidines
Ho, Son Long,Cho, Chan Sik
, p. 2705 - 2708 (2014/01/06)
β-Bromo α,β-unsaturated carboxylic acids were coupled and cyclized with amidine hydrochlorides by microwave irradiation in the presence of catalytic amounts of copper powder and a base to give the corresponding pyrimidinones in high yields. Georg Thieme Verlag Stuttgart New York.
Easy and efficient copper-catalyzed synthesis of bicyclic pyrimidinones under mild conditions
Guo, Qi,Yang, Haijun,Liu, Hongxia,Jiang, Yuyang,Fu, Hua
experimental part, p. 2611 - 2616 (2010/11/24)
A simple and efficient copper-catalyzed method has been developed for synthesis of bicyclic pyrimidinones containing six-, seven-, eight-membered rings under mild conditions. The protocol uses readily available 2-bromocycloalk-1-enecarboxylic acids, amidines, and guanidines as the starting materials, copper-catalyzed cascade couplings provide the corresponding bicyclic pyrimidinones without addition of any ligand or additive, and the method is of economical and practical advantages. Georg Thieme Verlag Stuttgart New York.
SATURATED HETEROCYCLES, XLVI SYNTHESIS OF 2-SUBSTITUTED-5,6-PENTAMETHYLENE-, 5,6-HEXAMETHYLENE- AND 5,6-DECAMETHYLENEPYRIMIDIN-4(3H)-ONES
Bernath, G.,Lazar, J.,Gera, L.,Goendoes, Gy.,Ecsery, Z.
, p. 231 - 236 (2007/10/02)
By the reactions of cycloheptanone-, cyclooctanone- and cyclodecanone-β-carboxylic esters and appropriate alkyl- or substituted aryl- and aralkyl amidines, several 2-substituted-5,6-pentamethylene-, 5,6-hexamethylene- and 5,6-decamethylenepyrimidin-4(3H)-one derivatives have been synthesized for pharmacological tests.
