912762-89-1

Basic information

• Product Name: 1-methyl-2-(3-methylphenyl)-1H-pyrrole
• Synonyms: 1-methyl-2-(3-methylphenyl)-1H-pyrrole
• CAS NO: 912762-89-1
• Molecular Weight: 171.242
• Mol File: 912762-89-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1-methyl-2-(3-methylphenyl)-1H-pyrrole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-methyl-2-(3-methylphenyl)-1H-pyrrole(912762-89-1)
• EPA Substance Registry System: 1-methyl-2-(3-methylphenyl)-1H-pyrrole(912762-89-1)

Safety Data

• Hazardous Substances Data: 912762-89-1(Hazardous Substances Data)

Upstream product

• 96-54-8 N-Methylpyrrole 
• 625-95-6 3-Iodotoluene 
• 197245-87-7 (2,4,6-trimethylphenyl)(3’-methylphenyl)iodonium triflate 
• 1416276-98-6 bis(3-methylphenyl)iodonium trifluoromethanesulfonate 

Relevant articles and documents

Generation of Aryl Radicals from Aryl Halides: Rongalite-Promoted Transition-Metal-Free Arylation

A new and practical method for the generation of aryl radicals from aryl halides is reported. Rongalite as a novel precursor of super electron donors was used to initiate a series of electron-catalyzed reactions under mild conditions. These transition-metal-free radical chain reactions enable the efficient formation of C-C, C-S, and C-P bonds through homolytic aromatic substitution or SRN1 reactions. Moreover, the synthesis of antipsychotic drug Quetiapine was performed on gram scale through the described method. This protocol demonstrated its potential as a promising arylation method in organic synthesis.

Determination of the inhibitory effects of N-methylpyrrole derivatives on glutathione reductase enzyme

Glutathione reductase (GR) is a crucial antioxidant enzyme which is responsible for the maintenance of antioxidant GSH molecule. Antimalarial effects of some chemical molecules are attributed to their inhibition of GR, thus inhibitors of this enzyme are expected to be promising candidates for the treatment of malaria. In this work, GR inhibitory properties of N-Methylpyrrole derivatives are reported. It was found that all compounds have better inhibitory activity than the strong GR inhibitor N,N-bis(2-chloroethyl)-N-nitrosourea, especially three molecules, 8 m, 8?n, and 8?q, were determined to be the most powerful among them. Findings of our study indicates that these Schiff base derivatives are strong GR inhibitors which can be used as leads for designation of novel antimalarial candidates.