91279-97-9Relevant academic research and scientific papers
SYNTHESIS OF ENANTIOMERICALLY PURE (S)-3-TRICHLOROMETHYLBUTYRIC ACID VIA ASYMMETRIC CONJUGATE ADDITION OF TRICHLOROMETHYL METAL COMPOUNDS TO A CHIRAL ENOATE. ACTIVATION EFFECT OF A SULFONYLAMINO GROUP.
Helmchen, Guenter,Wegner, Guenter
, p. 6047 - 6050 (2007/10/02)
(+)(S)-3-Trichloromethylbutyric acid, a building block for synthesis of various marine natural products, can be prepared via 99:1 stereoselective conjugate addition of Cl3CMgCl to the crotonate of a chiral auxiliary containing a sulfonylamino substituent.
