91285-61-9

Upstream product

• 57000-13-2 8-(benzylamino)-1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione 
• 100-46-9 benzylamine 
• 13487-89-3 diethyl 2-ethoxyethylmalonate 

Relevant academic research and scientific papers

Pyridonecarboxylic acid derivatives

This invention provides novel pyridonecarboxylic acid derivatives having a quite high antimicrobial activity. The derivatives have the following formula: STR1 wherein R1, R2 and R3 represent each a hydrogen or C1 -C6 alkyl group; R4 represents an ethyl, 2-fluoroethyl, vinyl, isopropyl, isopropenyl or cyclopropyl group; and X represents CH, C-F, C-Cl or N wherein (i) one of R1, R2 and R3 represents a hydrogen or C1 -C6 alkyl group, and (ii) either R1 forms a methylene chain having 2 to 4 carbon atoms together with R2 or R3, or R2 and R3 form together an alkylene chain having 2 to 5 atoms and R4 represents an ethyl, 2-fluorethyl, vinyl, isopropyl, isopropenyl or cyclopropyl group and X represents CH, C-F, or C-Cl and salt thereof.

Method of treating hyperploliferative skin disease with substituted-2,3-dihydro-6-substituted -pyrimido[2,1]-purine-4,8(1H,9H)diones

Substituted 2,3-dihydro-6-substituted-pyrimido[2,1-f]purine-4,8(1H,9H)-diones, their tautomers and salts, are disclosed for use as antihyperproliferative skin disease agents. Methods for their preparation and use are described.

Anti-inflammatory and anti-allergic substituted-2,3-dihydro-6-(hydroxy)pyrimido[2,1-f]-purine-4,8(1H,9H)-diones

Substituted 2,3-dihydro-6-(hydroxy)pyrimido[2,1-f]purine-4,8(1H,9H)-diones their tautomers and salts, are anti-inflammatory and anti-allergy agents. Methods for their preparation and use are described.

Anti-inflammatory substituted 9H-8-oxo-pyrimido[2,1-f]purine-2,4-diones

Substituted 9H-8-oxo-pyrimido[2,1-f]purine-2,4-diones their tautomers and salts are anti-inflammatory agents. Methods for their preparation and use are described.

REGIOSPECIFIC ALKYLATION OF 9-BENZYL-1,3-DIMETHYL-6-HYDROXYPYRIMIDOPURINE-2,4,8(1H,3H,9H)-TRIONE

The sodium salt of 9-benzyl-1,3-dimethyl-6-hydroxypyrimidopurine-2,4,8(1H,3H,9H)-trione (1a) reacted with a series of alkyl halides in N,N-dimethylformamide to yield 7-carbon alkylated products (1b-1).No O-alkylated products were detected.Isolated