912954-96-2

Upstream product

• 10257-28-0 D-Galactose 
• 1422008-08-9 methyl 2,3,5,6-tetra-O-benzyl-4-mesyl-D-glucose-oxime 
• 89539-39-9 2,3,5,6-tetra-O-benzyl-α/β-D-galactofuranose 

Downstream Products

• 912955-04-5 ethyl (2',3'-O-isopropylideneuridin-5'-yl)(2S,3aS,4S,5S,6S)-4,5-dibenzyloxy-6-[(1S)-1,2-dibenzyloxyethyl]hexahydropyrrolo[1,2-b]isoxazole-2-methylphosphonate 
• 912954-97-3 diethyl (2S,3aS,4S,5S,6S)-4,5-dibenzyloxy-6-[(1S)-1,2-dibenzyloxyethyl]hexahydropyrrolo[1,2-b]isoxazole-2-methylphosphonate 
• 912954-98-4 (1S)-2,3,5,6-tetra-O-benzyl-1,4-dideoxy-1-C-[(2S)-3-diethoxyphosphoryl-2-hydroxypropyl]-1,4-imino-D-galactitol 
• 912955-05-6 (1S)-2,3,5,6-tetra-O-benzyl-1,4-dideoxy-1-C-{(2S)-3-[(ethyl)(2',3'-O-isopropylideneuridin-5'-yl)phosphoryl]-2-hydroxypropyl}-1,4-imino-D-galactitol 
• 1083005-00-8 C₅₆H₆₁NO₁₀ 
• 1422007-98-4 methyl 5,6-tetradehydro-5,6,7,10-tetradeoxy-7,10-hydroxylamino-2,3,8,9,11,12-hexa-O-benzyl-D-galacto-β-D-galacto-dodecafuranose 
• 948897-76-5 3-((2S,3S,4S,5S)-5-((S)-1,2-bis(benzyloxy)ethyl)-3,4-bis(benzyloxy)-1-hydroxy-pyrrolidin-2-yl)propionic acid ethyl ester 

Relevant academic research and scientific papers

Design, synthesis and bioactivity evaluation of Galf mimics as antitubercular agents

A series of novel Galf mimics has been synthesized and characterized by IR, 1H NMR, 13C NMR, mass spectral and element analysis. All the newly prepared compounds were screened for their antitubercular activities. Bioactivity assays manifested that most of Galf mimics exhibited good antitubercular activities. Especially compound 4d and 4e displayed remarkable antitubercular efficacies, which were comparable to ethambutol.

Stereoselective synthesis of a novel Galf-disaccharide mimic: β-d-galactofuranosyl-(1-5)-β-d-galactofuranosyl motif of mycobacterial cell walls

A Galf-disaccharide mimic, an analogue of the acceptor substrates of mycobacterial Galf-transferases, was obtained by nucleophilic addition of a l-arabinofurano-alkyne to iminogalactitol-derived nitrone. Remarkably, the nucleophilic addition could be performed highly efficiently and stereoselectively in the presence of diethylzinc in toluene using protected nitrone and alkynyl sugar as reaction partners and thus opens a concise approach to a diversity of disaccharide mimics.

Diastereoselective synthesis of novel iminosugar-containing UDP-Galf mimics: Potential inhibitors of UDP-Gal mutase and UDP-Galf transferases

Tetra-O-benzyl-D-glucofuranose was converted into uridine diphosphono-β-Galf mimics based on an iminosugar skeleton linked to UMP by a 2-hydroxypropyl tether. The synthesis is based on the highly regio- and stereoselective cycloaddition of an original uri