91296-15-0

Basic information

• Product Name: 4-(2,6-diamino-9H-purin-9-yl)-2-(hydroxymethyl)cyclopentanol
• Synonyms: cyclopentanemethanol, 4-(2,6-diamino-9H-purin-9-yl)-2-hydroxy-
• CAS NO: 91296-15-0
• Molecular Formula: C₁₁H₁₆N₆O₂
• Molecular Weight: 264.2837
• Mol File: 91296-15-0.mol

Chemical Properties

• Boiling Point: 678.4°C at 760 mmHg
• Flash Point: 364.1°C
• Density: 1.92g/cm³
• Vapor Pressure: 2.49E-19mmHg at 25°C
• Refractive Index: 1.907
• CAS DataBase Reference: 4-(2,6-diamino-9H-purin-9-yl)-2-(hydroxymethyl)cyclopentanol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2,6-diamino-9H-purin-9-yl)-2-(hydroxymethyl)cyclopentanol(91296-15-0)
• EPA Substance Registry System: 4-(2,6-diamino-9H-purin-9-yl)-2-(hydroxymethyl)cyclopentanol(91296-15-0)

Safety Data

• Hazardous Substances Data: 91296-15-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-(2,6-diamino-9H-purin-9-yl)-2-(hydroxymethyl)cyclopentanol is used as a therapeutic agent for the treatment of alopecia areata. It is applied topically in a solution or cream form to stimulate an allergic response, which in turn promotes hair regrowth by activating the immune system to target the affected area.
However, it is important to note that DPCP can cause side effects such as dermatitis and allergic reactions. Therefore, its use should be under the guidance of a healthcare professional to ensure safe and effective treatment.

Upstream product

• 91296-11-6 (+/-)-(1R*,2S*,4S*)-4-(2-amino-6-chloro-9H-purin-9-yl)-2-(hydroxymethyl)-1-cyclopentanol 

Relevant articles and documents

Synthesis and Antiviral Activity of Carbocyclic Analogues of 2'-Deoxyribofuranosides of 2-Amino-6-substituted-purines and of 2-Amino-6-substituted-8-azapurines

(+/-)-(1α,2β,4α)-4--2-hydroxycyclopentanemethanol (9) was synthesized by beginning with 2-amino-4,6-dichloropyrimidine and (+/-)-(1α,2β,4α)-4-amino-2-hydroxycyclopentanemethanol, preparing the 5- derivative of the resulting pyrimidine, and reducing the azo derivative.The carbocyclic analogue of 2-amino-6-chloropurine 2'-deoxyribofuranoside (10) was prepared from 9 and triethyl orthoformate, and the analogous 8-azapurine (11) was obtained by diazotizing 9.From 10 or 11, the carbocyclic analogues of 2'-deoxyguanosine, 2'-deoxythioguanosine, 2,6-diaminopurine 2'-deoxyribofuranoside, 2'-deoxy-8-azaguanosine, and 2,6-diamino-8-azapurine 2'-deoxyribofuranoside were prepared.All of these 2'-deoxyribofuranoside analogues were active against herpes simplex virus (types 1 and 2) replicating in cells in culture; some demonstrated potent activity.