91296-87-6

Basic information

• Product Name: Sarafloxacin hydrochloride
• Synonyms: Sarafloxacin hydrochloride hydrate ;3-Quinolinec;6-fluoro-1-(4-fluorophenyl)-4-keto-7-piperazin-1-yl-quinoline-3-carboxylic acid hydrochloride;6-fluoro-1-(4-fluorophenyl)-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid hydrochloride;6-fluoro-1-(4-fluorophenyl)-4-oxo-7-piperazin-1-yl-1,4-dihydroquinoline-3-carboxylic acid hydrochloride;Sarafloxacin hydrochloride trihydrate;3-Quinolinecarboxylicacid, 6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-7-(1-piperazinyl)-;6-Fluoro-1-(4-fluorophenyl)-4-oxo-7-piperazin-1-yl-1,4-dihydroquinoline-3-carboxylic acid hydr
• CAS NO: 91296-87-6
• Molecular Formula: C₂₀H₁₇F₂N₃O₃*ClH
• Molecular Weight: 421.83
• EINECS: 1806241-263-5
• Product Categories: Pharmacutical raw materials;Active Pharmaceutical Ingredients;Aromatics;Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 91296-87-6.mol
• Article Data: 1

Chemical Properties

• Melting Point: >240°C (dec.)
• Boiling Point: 621.4 °C at 760 mmHg
• Flash Point: >110°(230°F)
• Appearance: pale yellow solid
• Vapor Pressure: 2.67E-16mmHg at 25°C
• Storage Temp.: 0-6°C
• Solubility: DMSO (Slightly), Methanol (Very Slightly, Heated)
• Water Solubility: Soluble in water
• CAS DataBase Reference: Sarafloxacin hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: Sarafloxacin hydrochloride(91296-87-6)
• EPA Substance Registry System: Sarafloxacin hydrochloride(91296-87-6)

Safety Data

• Safety Statements: 24/25
• WGK Germany: 3
• Hazardous Substances Data: 91296-87-6(Hazardous Substances Data)

Usage

Chemical Properties

Pale Yellow Solid

Uses

Different sources of media describe the Uses of 91296-87-6 differently. You can refer to the following data:
1. Sarafloxacin is a fluorinated quinolone antibacterial.
2. progestin, antiandrogen
3. A fluoroquinolone antibacterial agent

Brand name

SaraFlox Injectable (Abbott); SaraFlox WSP (Abbott).

InChI:InChI=1/C20H17F2N3O3.ClH/c21-12-1-3-13(4-2-12)25-11-15(20(27)28)19(26)14-9-16(22)18(10-17(14)25)24-7-5-23-6-8-24;/h1-4,9-11,23H,5-8H2,(H,27,28);1H

Downstream Products

• 98105-99-8 sarafloxacin 

Relevant articles and documents

Preparation method of quinolone carboxylic acid derivative or phthalazinone carboxylic acid derivative

The invention belongs to the field of pharmaceutical chemicals, relates to a preparation method of a quinolone carboxylic acid derivative or a phthalazinone carboxylic acid derivative, and particularly relates to a preparation method of a 7-substituted-3-quinolone carboxylic acid derivative or a 7-substituted-1,5-phthalazinone carboxylic acid derivative. The preparation method comprises the following steps: (1) in an organic solvent, carrying out coupling reaction on a boron chelate II and organic amine III in the presence of an organosilicon compound to obtain a compound IV; and (2) mixing the compound IV with hydrochloric acid, and then filtering and separating the precipitated compound I. Compared with conventional methods, the preparation method provided by the invention has the advantages that the conditions are milder, the hydrolysis of the substrate quinoline carboxylic acid boric acid ester can be reduced, and meanwhile, the influence of a byproduct HF on the product purity is avoided. The method is high in yield and high in purity; compared with the traditional alkali, the organic silicon is more suitable for industrial preparation of the 7-substituted-3-quinolone carboxylic acid derivative or the 7-substituted-1,5-phthalazinone carboxylic acid derivative.