912968-69-5Relevant academic research and scientific papers
Optimization of benzyloxazoles as non-nucleoside inhibitors of HIV-1 reverse transcriptase to enhance Y181C potency
Bollini, Mariela,Gallardo-Macias, Ricardo,Spasov, Krasimir A.,Tirado-Rives, Julian,Anderson, Karen S.,Jorgensen, William L.
, p. 1110 - 1113 (2013/03/14)
Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved activity towards Tyr181Cys containing variants was pursued with the assistance of free energy perturbation (FEP) calculations. Optimization of the 4-R substituent in 1 led to ethyl and isopropyl analogs 1e and 1f with 1-7 nM potency towards both the wild-type virus and a Tyr181C variant.
On the illusive nature of o-formylazobenzenes: Exploiting the nucleophilicity of the azo group for cyclization to indazole derivatives
Peters, Maike V.,Stoll, Ragnar S.,Goddard, Richard,Buth, Gernot,Hecht, Stefan
, p. 7840 - 7845 (2007/10/03)
(Chemical Equation Presented) Facile rearrangement of azobenzenes is shown to occur in cases where the azo group is placed in the ortho position to carbonyl electrophiles to furnish the indazole skeleton. While this study demonstrates the illusive nature
