913003-14-2 Usage
Derivative of indazole
Indazole is a bicyclic aromatic heterocycle 1H-Indazole, 4-bromo-1-(4-fluorophenyl)-6-methyl- is based on the structure of indazole, which is a bicyclic (two interconnected rings) aromatic (having a stable, delocalized electron system) heterocycle (a ring containing atoms of more than one element, in this case, carbon and nitrogen).
Bromine substituent at the 4 position
A bromine atom replaces one hydrogen atom at the 4th position of the indazole ring The presence of a bromine atom at this position can influence the compound's reactivity, polarity, and lipophilicity (ability to dissolve in lipids).
Fluorophenyl group at the 1 position
A phenyl ring with a fluorine atom (C6H4F) is connected to the 1st position of the indazole ring The fluorine atom in the phenyl group can influence the compound's electronic properties, such as reactivity and binding affinity to target proteins.
Member of the indazole class of chemicals
1H-Indazole, 4-bromo-1-(4-fluorophenyl)-6-methyl- belongs to a group of chemical compounds that share a similar indazole structure This classification can be useful for understanding the compound's potential applications and properties in comparison to other indazole derivatives.
Potential candidate for pharmaceutical research
The molecular structure and properties of 1H-Indazole, 4-bromo-1-(4-fluorophenyl)-6-methyl- make it a promising candidate for the development of new therapeutic drugs Researchers may explore its potential as a drug candidate due to its unique structure and properties.
Building block in the synthesis of new pharmacologically active compounds
1H-Indazole, 4-bromo-1-(4-fluorophenyl)-6-methyl- is often used as an intermediate in the synthesis of other pharmacologically active molecules Its versatile structure allows for further chemical modifications, which can lead to the development of new drugs with improved efficacy and safety profiles.
Check Digit Verification of cas no
The CAS Registry Mumber 913003-14-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,1,3,0,0 and 3 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 913003-14:
(8*9)+(7*1)+(6*3)+(5*0)+(4*0)+(3*3)+(2*1)+(1*4)=112
112 % 10 = 2
So 913003-14-2 is a valid CAS Registry Number.
913003-14-2Relevant academic research and scientific papers
Highly tractable, sub-nanomolar non-steroidal glucocorticoid receptor agonists
Biggadike, Keith,Caivano, Matilde,Clackers, Margaret,Coe, Diane M.,Hardy, George W.,Humphreys, Davina,Jones, Haydn T.,House, David,Miles-Williams, Annette,Skone, Philip A.,Uings, Iain,Weller, Vicki,McLay, Iain M.,Macdonald, Simon J.F.
scheme or table, p. 4846 - 4850 (2010/05/18)
Starting from a non-steroidal glucocorticoid agonist aryl pyrazole derivative, the NFκB agonist activity was optimised in an iterative process from pIC50 7.5 (for 7), to pIC50 10.1 (for 38E1). An explanation for the SAR observed base
NOVEL COMPOUNDS
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Page/Page column 70, (2008/06/13)
The present invention provides glucocorticoid receptor agonists of formula (I), a process for their preparation, pharmaceutical compositions comprising the compounds and the preparation of said compositions, intermediates and use of the compounds for the
INDAZOLES AS GLUCOCORTICOID RECEPTOR LIGANDS
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Page/Page column 49, (2008/06/13)
The present invention is directed to compounds of formula (I): wherein A1 represents 2,3-dihydro-1-benzofuran-7-yl, 5-fluoro-2-methoxy-phenyl or 5-fluoro-2-hydroxy-phenyl; X represents -C(R3)- or nitrogen; when X represents -C(R3)-, R2 represents hydrogen and R1 represents fluorine, R3 represents hydrogen or fluorine, when X represents -C(R3)- and R2 and R1 each represent hydrogen, R3 represents hydrogen, hydroxy, methoxy or fluorine, when X represents -C(R3)- and R2 represents hydroxy, methoxy, -CO2CH3 or -CO2CH2CH3, R1 and R3 each represent hydrogen, when X represents nitrogen, R1 and R2 each represent hydrogen; and Y represents H or methyl; and physiologically functional derivatives thereof, pharmaceutical compositions and formulations comprising the compounds, the use of the compounds for the manufacture of medicaments particularly for the treatment of inflammatory and/or allergic conditions and/or skin diseases, processes for the preparation of the compounds, and chemical intermediates in the processes for the manufacture of the compounds.
