913055-79-5Relevant academic research and scientific papers
A novel synthetic approach to 4-acetamido-1-arylindazoles via Semmler-Wolff rearrangement of 1-aryl-6,7-dihydro-5H-indazol-4-one oxime
Manjunatha, Sulur G.,Bachu, Sreekanth,Kadambar, Vasantha Krishna,Murugan, Andiappan,Ramasubramanian, Sridharan,Ramachandra, Puranik,Nambiar, Sudhir
, p. 3348 - 3350 (2014/06/09)
A simple and efficient procedure for the syntheses of 4-acetamido-1- arylindazoles from corresponding 1-aryl-6,7-dihydro-5H-indazol-4-one oximes by Semmler-Wolff aromatization using acetic anhydride and sodium iodide is reported.
Highly tractable, sub-nanomolar non-steroidal glucocorticoid receptor agonists
Biggadike, Keith,Caivano, Matilde,Clackers, Margaret,Coe, Diane M.,Hardy, George W.,Humphreys, Davina,Jones, Haydn T.,House, David,Miles-Williams, Annette,Skone, Philip A.,Uings, Iain,Weller, Vicki,McLay, Iain M.,Macdonald, Simon J.F.
scheme or table, p. 4846 - 4850 (2010/05/18)
Starting from a non-steroidal glucocorticoid agonist aryl pyrazole derivative, the NFκB agonist activity was optimised in an iterative process from pIC50 7.5 (for 7), to pIC50 10.1 (for 38E1). An explanation for the SAR observed base
NOVEL COMPOUNDS
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Page/Page column 61, (2008/06/13)
The present invention provides glucocorticoid receptor agonists of formula (I), a process for their preparation, pharmaceutical compositions comprising the compounds and the preparation of said compositions, intermediates and use of the compounds for the
