91306-27-3

Upstream product

• 91306-28-4 3'-benzyl-5,5,5',5'-tetramethylcyclohexanespiro-2'-oxazolidine-3,4'-dione 
• 126-81-8 dimedone 
• 100-46-9 benzylamine 
• 344584-70-9 3'-benzyl-5,5,5',5'-tetramethyl-3-phenyliminocyclohexanespiro-2'-oxazolidin-4'-one 
• 889-31-6 5,5-dimethyl-3-benzylamino-2-cyclohexen-1-one 
• 18940-21-1 5,5-dimethyl-3-(phenylamino)cyclohex-2-en-1-one 

Relevant academic research and scientific papers

Base-promoted Reactions of β-Enaminones with 2-Bromo-2-methylpropanamides. Formation of 2-Ketonyloxazolidin-4-ones and Cyclohexanespiro-oxazolidin-4-ones

Representative β-enaminones (1) and (2) react with N-alkyl-2-bromo-2-methylpropanamides (4a), (4b), and (4c) in the presence of NaH, to afford oxazolidin-4-ones (5) and (6) or spiro-oxazolidinone derivatives (7) and (8).The formation of an imidazolidin-4-one derivative (9) from 2-bromo-2-methylpropanilide (4c) is ascribed to the presence of an intermediate α-lactam (15).The behaviour of a spiro-oxazolidinone derivative on hydrolysis, reduction, and thiation is described.