913092-76-9

Upstream product

• 913092-75-8 N-[2-oxo-2-(4-oxo-3-phenylpiperidin-1-yl)ethyl]acetamide 
• 2627-86-3 (S)-1-phenyl-ethylamine 

Downstream Products

• 913092-77-0 N-{2-[(3R,4S)-4-amino-3-phenylpiperidin-1-yl]-2-oxoethyl}acetamide 

Relevant academic research and scientific papers

PIPERIDINE DERIVATIVE AS TACHYKININ RECEPTOR ANTAGONIST

The present invention relates to a compounds represented by the formula. The compounds of the present invention have a superior tachykinin receptor antagonistic action, particularly a substance P receptor antagonistic action, and is useful as pharmaceutical agents, for example, tachykinin receptor antagonists, agents for the prophylaxis or treatment of lower urinary tract symptoms, gastrointestinal diseases or central nerve diseases.

PIPERIDINE DERIVATIVES AS TACHYKININ RECEPTOR ANTAGONISTS

A novel piperidine derivative represented by the formula (I) (I) wherein Ar is a phenyl group optionally having substituent(s), R?1? is a hydrogen atom, a hydrocarbon group optionally having substituent(s), an acyl group or a heterocyclic group optionally having substituent(s), Z is a methylene group optionally having C?1-6#191 alkyl group(s), ring A is a piperidine ring optionally further having substituent(s), and B is a monocyclic aromatic heterocyclic group optionally having substituent(s) (substituents of monocyclic aromatic heterocycle may be bonded to each other to form a ring), or a salt thereof has a superior tachykinin receptor antagonistic action and the like, and is useful as an agent for the prophylaxis or treatment of lower urinary tract disease and the like.

Piperidine derivative crystal, process for producing the same, and use

The present invention provides a piperidine derivative having antagonistic action for tachykinin receptors and the like, a crystal thereof, and an agent for the prophylaxis or treatment of diseases including lower urinary tract disease and the like, which contains the derivative. Specifically, the present invention provides an optically active compound represented by the formula (I): wherein each symbol is as defined in the specification, and a salt thereof.