913169-22-9Relevant academic research and scientific papers
Sequential amino-Claisen rearrangement/intramolecular 1,3-dipolar cycloaddition/reductive cleavage approach to the stereoselective synthesis of cis-4-hydroxy-2-aryl-2,3,4,5-tetrahydro-1(1H)-benzazepines
Ayala, Sandra Liliana Gómez,Stashenko, Elena,Palma, Alirio,Bahsas, Alí,Amaro-Luis, Juan Manuel
, p. 2275 - 2277 (2006)
A novel stereoselective synthesis of cis-2-aryl-4-hydroxy-2,3,4,5- tetrahydro-1-benzazepines from N-allylanilines utilizing aromatic amino-Claisen rearrangement and intramolecular 1,3-dipolar cycloaddition methodologies is described. This sequence involve
Synthesis, structural elucidation and in vitro antiparasitic activity against Trypanosoma cruzi and Leishmania chagasi parasites of novel tetrahydro-1-benzazepine derivatives
Gomez-Ayala, Sandra,Castrillon, Julian A.,Palma, Alirio,Leal, Sandra M.,Escobar, Patricia,Bahsas, Ali
experimental part, p. 4721 - 4739 (2010/08/22)
Forty six new 1,4-epoxy-2-exo-aryl- and cis-2-aryl-4-hydroxytetrahydro-1- benzazepine derivatives were synthesized and fully characterized. All compounds were tested in vitro against both Trypanosoma cruzi and Leishmania chagasi parasites and also for cyt
