913176-63-3

Upstream product

• 280120-69-6 [1-(3-cyano-4-fluoro)phenyl]-3-methyl-4-nitropyrazole-5-carboxylic acid 
• 209959-21-7 Ethyl [1-(3-cyano-4-fluoro)phenyl]-3-methylpyrazole-5-carboxylate 
• 280120-72-1 [1-(3-cyano-4-fluoro)phenyl]-3, 5-dimethyl-6-(4-bromophenyl)-1,6-dihydropyrazolo-[4,3-d]-pyrimidin-7-one 
• 280120-70-9 [1-(3-cyano-4-fluoro)phenyl]-3-methyl-4-nitro-5-[(4-bromophenyl)aminocarbonyl]pyrazole 
• 280120-71-0 [1-(3-cyano-4-fluoro)phenyl]-3-methyl-4-amino-5-[(4-bromophenyl)aminocarbonyl]pyrazole 
• 280120-68-5 Ethyl [1-(3-cyano-4-fluoro)phenyl]-3-methyl-4-nitro pyrazole-5-carboxylate 
• 913176-61-1 2-fluoro-5-[6-(2'-hydroxymethyl-biphenyl-4-yl)-3,5-dimethyl-7-oxo-6,7-dihydro-pyrazolo[4,3-d]pyrimidin-1-yl]-benzonitrile 
• 913176-59-7 2-fluoro-5-[6-(2'-formyl-biphenyl-4-yl)-3,5-dimethyl-7-oxo-6,7-dihydro-pyrazolo[4,3-d]pyrimidin-1-yl]-benzonitrile 

Downstream Products

• 280120-73-2 4'-[1-(3-amino-benzo[d]isoxazol-5-yl)-3,5-dimethyl-7-oxo-1,7-dihydro-pyrazolo[4,3-d]pyrimidin-6-yl]-biphenyl-2-carbaldehyde 

Relevant academic research and scientific papers

Preparation of 1-(3-aminobenzo[d]isoxazol-5-yl)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-ones as potent, selective, and efficacious inhibitors of coagulation factor Xa

Previously, potent factor Xa inhibitors were described based on the 1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one bicyclic core and a 4-methoxyphenyl P1 moiety. This manuscript describes 1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one and related bicyclic cores with the 3-