913176-85-9

Upstream product

• 209960-58-7 1-(3-cyano-4-fluorophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic Acid 
• 280119-96-2 [1-(3-cyano-4-fluorophenyl)]-3-trifluoromethyl-4-nitro-pyrazole-5-carboxylic acid 
• 913176-80-4 2-(4-bromo-phenyl)-3-[2-(3-cyano-4-fluoro-phenyl)-4-nitro-5-trifluoromethyl-2H-pyrazol-3-yl]-3-oxo-propionic acid methyl ester 
• 913176-82-6 5-{4-amino-5-[(4-bromo-phenyl)-acetyl]-3-trifluoromethyl-pyrazol-1-yl}-2-fluoro-benzonitrile 

Relevant academic research and scientific papers

Preparation of 1-(3-aminobenzo[d]isoxazol-5-yl)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-ones as potent, selective, and efficacious inhibitors of coagulation factor Xa

Previously, potent factor Xa inhibitors were described based on the 1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one bicyclic core and a 4-methoxyphenyl P1 moiety. This manuscript describes 1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one and related bicyclic cores with the 3-