913193-72-3

Upstream product

• 913193-91-6 (3R)-3-hydroxy-4-(tert-butyldiphenylsilanyloxy)butyric acid benzyl ester 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 81927-55-1 O-benzyl 2,2,2-trichloroacetimidate 
• 913193-71-2 (3R)-3-benzyloxy-4-(tert-butyldiphenylsilanyloxy)butyric acid benzyl ester 

Downstream Products

• 623566-45-0 [(2R,3S,6S)-6-((2R)-2-benzyloxy-6-methylhept-3-enyl)-3-methyltetrahydropyran-2-yl]acetaldehyde 
• 913193-75-6 (3R,5R)-5-benzyloxy-1-iodo-3-(tert-butyldimethylsilanyloxy)-6-(tert-butyldiphenylsilanyloxy)hexane 
• 913193-74-5 (3S,5R)-5-benzyloxy-3-(tert-butyldimethylsilanyloxy)-6-(tert-butyldiphenylsilanyloxy)hexan-1-ol 
• 913193-73-4 (4S,6R)-6-benzyloxy-4-(tert-butyldimethylsilanyloxy)-7-(tert-butyldiphenylsilanyloxy)hept-1-ene 
• 913193-93-8 5-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-6-(tert-butyl-diphenyl-silanyloxy)-hexanal 
• 913193-79-0 acetic acid (3S,6S)-6-((2R)-2-benzyloxy-6-methylhept-3-enyl)-3-methyltetrahydropyran-2-yl ester 
• 913193-78-9 (3S,6S)-6-((2R)-2-benzyloxy-6-methylhept-3-enyl)-3-methyltetrahydropyran-2-one 
• 913193-95-0 (3S,6S)-6-((E)-(R)-2-Benzyloxy-6-methyl-hept-3-enyl)-3-methyl-tetrahydro-pyran-2-ol 
• 913193-77-8 (2S,5S,7R)-7-Benzyloxy-5,8-dihydroxy-2-methyl-octanoic acid 
• 913193-94-9 (3S,6S)-6-((2R)-2-benzyloxy-3-hydroxypropyl)-3-methyltetrahydropyran-2-one 
• 502160-06-7 (2R)-2-(benzyloxy)-3-[(2S,5S)-5-methyl-6-oxo-tetrahydro-2H-pyran-2-yl]propanal 

Relevant academic research and scientific papers

[4 + 2]-Annulations of chiral organosilanes: Application to the total synthesis of leucascandrolide A

Complete details of an asymmetric synthesis of leucascandrolide A (1) are described. The synthesis highlights the use of two diastereoselective [4 + 2]-annulations for the assembly of the functionalized bispyranyl macrolide 3. An efficient assembly and un