91326-10-2Relevant academic research and scientific papers
DIRECTION OF THE REACTION OF β-KETO ESTERS WITH ORTHANILAMIDES
Solomko, Z.F.,Fedenko, V.S.,Avramenko, V.I.
, p. 534 - 539 (2007/10/02)
Depending on the conditions and on the ratio of the reagents, the condensation of β-keto esters with orthanilamides leads to enamines, imines, or anilides, which undergo cyclization to derivatives of 1,2,4-benzothiadiazine 1,1-dioxide.Under mild conditions the β-keto esters give enamines (with the β-keto ester and orthanilamide in a ratio of 3:1), and with a small exces of ethyl 2-cyclopentanonecarboxylate (1:2:1) a mixture of the isomeric ketimine and enamine is formed.
