913377-85-2

Upstream product

• 1122-91-4 4-bromo-benzaldehyde 
• 913377-83-0 7-methoxy-4-(phenylsulfinyl)quinoline 
• 913377-82-9 7-methoxy-4-(phenylthio)quinoline 
• 68500-37-8 4-chloro-7-methoxyquinoline 
• 913377-84-1 (4-bromophenyl)-(7-methoxyquinolin-4-yl)methanol 

Downstream Products

• 913377-88-5 N-(4-(hydroxy(7-(methyloxy)-4-quinolinyl)methyl)phenyl)-5-methyl-3-oxo-2-phenyl-1-propyl-2,3-dihydro-1H-pyrazole-4-carboxamide 

Relevant academic research and scientific papers

Aurora Kinase Modulators and Method of Use

The present invention relates to chemical compounds having a general formula I wherein A1-8, D′, L1, L2, R1, R6-8 and n are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of such kinases. For example, the compounds are capable of modulating Aurora kinase thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of Aurora kinase.

SUBSTITUTED AMIDE DERIVATIVES AS PROTEIN KINASE INHIBITORS

Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.