913382-75-9Relevant academic research and scientific papers
Antitumour properties of fluorinated benzothiazole-substituted hydroxycyclohexa-2,5-dienones ('quinols')
Lion, Cedric J.,Matthews, Charles S.,Wells, Geoffrey,Bradshaw, Tracey D.,Stevens, Malcolm F.G.,Westwell, Andrew D.
, p. 5005 - 5008 (2008/12/23)
The synthesis and in vitro antitumour evaluation of a new series of fluorinated benzothiazole-substituted 4-hydroxycyclohexa-2,5-dienones ('quinols') is described. The new compounds were found to be of comparable activity compared to the non-fluorinated precursor PMX 464, in terms of antiproliferative activity in sensitive human cancer cell lines (nanomolar GI50 values) and inhibitory activity against the thioredoxin signalling system.
