91344-69-3Relevant academic research and scientific papers
Design, synthesis, and biological evaluation of hydroquinone derivatives as novel inhibitors of the sarco/endoplasmic reticulum calcium ATPase
Paula, Stefan,Abell, Josh,Deye, Joel,Elam, Christopher,Lape, Michael,Purnell, Justin,Ratliff, Robert,Sebastian, Kelly,Zultowsky, Jodie,Kempton, Robert J.
experimental part, p. 6613 - 6619 (2009/12/24)
Analogues of the compound 2,5-di-tert-butylhydroquinone (BHQ) are capable of inhibiting the enzyme sarco/endoplasmic reticulum ATPase (SERCA) in the low micromolar and submicromolar concentration ranges. Not only are SERCA inhibitors valuable research tools, but they also have potential medicinal value as agents against prostate cancer. This study describes the synthesis of 13 compounds representing several classes of BHQ analogues, such as hydroquinones with a single aromatic substituent, symmetrically and unsymmetrically disubstituted hydroquinones, and hydroquinones with ω-amino acid tethers attached to their hydroxyl groups. Structure-activity relationships were established by measuring the inhibitory potencies of all synthesized compounds in bioassays. The assays were complemented by computational ligand docking for an analysis of the relevant ligand/receptor interactions.
LIQUID CRYSTAL COMPOUNDS
-
Page 9; 22, (2008/06/13)
In one embodiment, the invention relates to compounds of the formula (I)wherein G1 and G2 independently represent a polymerizable mesogenic residue, and X, Sp, and Q are as defined herein. The compounds of the invention may, for example, be useful as cura
A Convenient Synthesis of 2-Alkylated 1,4-Benzenediols
Ozaki, Yutaka,Hosoya, Ayako,Okamura, Kyouko,Kim, Sang-Won
, p. 365 - 366 (2007/10/03)
Reaction of 1,4-cyclohexanedione with a variety of aldehydes in the presence of metal halides generated the 2-alkylated 1,4-benzenediols in good yields without any aromatic by-products.
