91348-39-9

Usage

Structure

Quinolinone derivative with a bromomethyl and methyl group attached to the quinoline ring

Usage

Organic synthesis and pharmaceutical research

Potential

Biological activity, potential applications in medicinal chemistry

Value

Building block for the synthesis of novel drug candidates and bioactive molecules due to the presence of the bromomethyl group for further chemical modifications.

Upstream product

• 2584-47-6 1,4-dimethylquinolin-2(1H)-one 
• 100-61-8 N-methylaniline 

Downstream Products

• 909697-47-8 4-(2-bromo-4-methyl-phenoxymethyl)-1-methyl-1H-quinolin-2-one 
• 909697-43-4 4-(2-bromo-4-methoxy-phenoxymethyl)-1-methyl-1H-quinolin-2-one 
• 909697-48-9 4-(2-bromo-phenoxymethyl)-1-methyl-1H-quinolin-2-one 
• 909697-46-7 4-(2-bromo-4,6-dimethyl-phenoxymethyl)-1-methyl-1H-quinolin-2-one 
• 944048-37-7 C₁₈H₁₆BrNOS 
• 944048-38-8 C₁₉H₁₈BrNOS 
• 944048-39-9 C₁₇H₁₄BrNOS 
• 1174908-80-5 C₁₈H₁₇BrN₂O 
• 1174908-83-8 C₁₉H₁₉BrN₂O 
• 1174908-86-1 C₂₀H₂₁BrN₂O 

Relevant academic research and scientific papers

Carbon-carbon bond formation by radical cyclization: Regioselective synthesis of spiro heterocyclic compounds by nBu3SnH- mediated reaction

Several spiro heterocyclic compounds have been regioselectively synthesized in excellent yield by n Bu 3 SnH-AIBN-mediated radical cyclization of 4-(2′-bromoaryloxymethyl)-1-methylquinolin-2(1 H )-ones in refluxing benzene under nitrogen for 4 h. Copyrigh

Carbostyril derivatives and antiallergic agent

1. A compound of the formula: STR1 wherein the symbol of a solid line with a broken line means a single bond or a double bond,R and R'' are independently selected from the group consisting of hydrogen atom, halogen atom, lower alkyl, nitro, unsubstituted amino and substituted amino,A and B are independently selected from the group consisting of hydrogen atom, lower alkyl optionally substituted with a lower cycloalkyl, aryl optionally substituted with one or more halogen atoms and the group: -Y-R 2wherein Y is lower alkylene and R 2 is the group: STR2 wherein m is integer of 1 to 3, n is 0 or 1, Z is >N-, >CH-- or >C=, R 3 is diaryl (lower) alkyl optionally substituted with one or more halogen atoms or is condensed heterocyclic group optionally substituted with oxo, with the proviso that(a) at least one of A and B is the group -Y-R 2 and(b) when A is hydrogen atom and B is the group -Y-R 2, then Z is >CH-- or >C= if R 3 is condensed heterocyclic group optionally substituted with oxo and n is Oor a pharmaceutically acceptable salt thereof. The compounds of the above formula have antiallergic activity.