91350-01-5

Usage

Uses

Used in Pharmaceutical Industry:
4-(Isopropylamino-methyl)-benzonitrile is used as a building block for the synthesis of various pharmaceuticals due to its versatile reactivity and biological activity. Its structural features and potential pharmacological properties make it a promising candidate for drug development.
Used in Agrochemical Industry:
4-(IsopropylaMino-Methyl)-benzonitrile is also used as a building block in the synthesis of agrochemicals, contributing to the development of new and effective products for agricultural applications.
Used in Organic Synthesis:
4-(Isopropylamino-methyl)-benzonitrile serves as a reagent in organic synthesis, facilitating the creation of a wide range of chemical products.
Used in Specialty Chemicals Manufacturing:
It is employed in the manufacture of dyes, pigments, and other specialty chemicals, enhancing the properties and applications of these products.
Used in Medicinal Chemistry Research:
Due to its structural features and potential pharmacological properties, 4-(Isopropylamino-methyl)-benzonitrile may have potential applications in medicinal chemistry research, aiding in the discovery and development of new therapeutic agents.

Upstream product

• 75-31-0 isopropylamine 
• 105-07-7 4-cyanobenzaldehyde 
• 70380-44-8 4-cyano-N-isopropylbenzamide 
• 17201-43-3 4-cyanobenzyl bromide 

Downstream Products

• 928649-03-0 4-[N-(tert-butoxycarbonyl)-N-(iso-propyl)-aminomethyl]-benzonitrile 

Relevant academic research and scientific papers

Mild Metal-Free Hydrosilylation of Secondary Amides to Amines

The combination of amide activation by Tf2O with B(C6F5)3-catalyzed hydrosilylation with TMDS constitutes a method for the one-pot reduction of secondary amides to amines under mild conditions. The method displays a broad applicability for the reduction of many types of substrates, and shows good compatibility and excellent chemoselectivity for many sensitive functional groups. Reductions of a multifunctionalized α,β-unsaturated amide obtained from another synthetic methodology, and a C-H functionalization product produced the corresponding amines in good to excellent yield. Chemoselective reduction of enantiomeric pure (ee >99%) tetrahydro-5-oxo-2-furaneamides yielded 5-(aminomethyl)dihydrofuran-2(3H)-ones in a racemization-free manner. The latter were converted in one pot to N-protected 5-hydroxypiperidin-2-ones, which are building blocks for the synthesis of many natural products. Further elaboration of an intermediate led to a concise four-step synthesis of -epi-pseudoconhydrine.

Part 1: Notch-sparing γ-secretase inhibitors: The identification of novel naphthyl and benzofuranyl amide analogs

γ-Secretase is one of two proteases directly involved in the production of the amyloid β-peptide (Aβ), which is pathogenic in Alzheimer's disease. Inhibition of γ-secretase to suppress the production of Aβ should not block processing of one of its alterna

6-ARYLALKYLAMINO- 2,3,4,5-TETRAHYDRO-1H-BENZO[D]AZEPINES AS 5-HT2C RECEPTOR AGONISTS

The present invention provides 6-substituted 2,3,4,5-tetrahydro-lH- benzo[d]azepines of Formula (I) as selective 5-HT2c receptor agonists for the treatment of 5-HT2c associated disorders including obesity, obsessive/compulsive disorder, depression, and anxiety, where, R6 is -NR10R11, where R10 is substituted phenylalkyl or substituted pyridylalkyl and other substituents are as defined in the specification.