913563-91-4Relevant academic research and scientific papers
RCM-mediated synthesis of trifluoromethyl-containing nitrogen heterocycles
De Matteis, Valeria,Van Delft, Floris L.,Jakobi, Harald,Lindell, Stephen,Tiebes, Joerg,Rutjes, Floris P. J. T.
, p. 7527 - 7532 (2007/10/03)
(Chemical Equation Presented) A ring-closing metathesis mediated pathway to trifluoromethyl-containing piperidines is detailed. This involves the development of a synthetic route to a new (trifluoromethyl)allylating reagent via a Diels-Alder/retro-Diels-Alder strategy, its application in the synthesis of a series of trifluormethyl-substituted diolefin recursors for ring-closing metathesis, and eventually the successful cyclization of these precursor molecules into the corresponding functionalized piperidines.
