913568-03-3Relevant academic research and scientific papers
SUBSTITUTE 1, 6-NAPHTHYRIDINES FOR USE AS SCD INHIBITORS
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Page/Page column 34-35, (2009/06/27)
The present invention relates to substituted tetrahydronaphthyridine (THN) compounds of the formula (I) and salts thereof, to pharmaceutical compositions containing them and their use in medicine. In particular, the invention relates to compounds for inhibiting SCD activity.
Discovery of brain penetrant, soluble, pyrazole amide EP1 receptor antagonists
Hall, Adrian,Billinton, Andy,Bristow, Alan K.,Brown, Susan H.,Chowdhury, Anita,Cutler, Leanne,Giblin, Gerard M.P.,Goldsmith, Paul,Hayhow, Thomas G.,Kilford, Ian R.,Naylor, Alan,Passingham, Barry,Rawlings, D. Anthony
scheme or table, p. 4027 - 4032 (2009/04/10)
We describe the discovery of a series of pyrazole amide EP1 receptor antagonists with good aqueous solubility and CNS penetration. In order to achieve solubility we investigated the incorporation of a basic group in the region of the molecule p
Non-acidic pyrazole EP1 receptor antagonists with in vivo analgesic efficacy
Hall, Adrian,Billinton, Andy,Brown, Susan H.,Clayton, Nicholas M.,Chowdhury, Anita,Giblin, Gerard M.P.,Goldsmith, Paul,Hayhow, Thomas G.,Hurst, David N.,Kilford, Ian R.,Naylor, Alan,Passingham, Barry,Winyard, Lisa
scheme or table, p. 3392 - 3399 (2009/04/06)
Replacement of the carboxylic acid group in a series of previously described methylene-linked pyrazole EP1 receptor antagonists led to the discovery of amide, reversed amide and carbamate derivatives. Two compounds, 10a and 10b, were identified
PYRAZOLE COMPOUNDS AS PROSTAGLANDIN RECEPTORS LIGANDS
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Page/Page column 50-51, (2008/06/13)
Compounds of formula (I) or a pharmaceutically acceptable derivative thereof: wherein Z, R1 ,R2a, R2b, R10, R11 and Rx are as defined in the specification, a process for the preparation of such compounds, pharmaceutical compositions comprising such compounds and the use of such compounds in medicine.
