913573-39-4Relevant academic research and scientific papers
ROR [gamma]t inhibitor, preparation method and application thereof
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Paragraph 0740; 0742-0744, (2021/07/08)
The invention relates to the technical field of medicines, in particular to an ROR [gamma]t inhibitor, a preparation method and application thereof. The invention also relates to a pharmaceutical composition containing the compound, a method for preparing the pharmaceutical composition, and application of the compound or the pharmaceutical composition in treatment or prevention of ROR [gamma]t-mediated cancers, inflammations or autoimmune diseases of mammals, especially human beings.
Discovery of brain penetrant, soluble, pyrazole amide EP1 receptor antagonists
Hall, Adrian,Billinton, Andy,Bristow, Alan K.,Brown, Susan H.,Chowdhury, Anita,Cutler, Leanne,Giblin, Gerard M.P.,Goldsmith, Paul,Hayhow, Thomas G.,Kilford, Ian R.,Naylor, Alan,Passingham, Barry,Rawlings, D. Anthony
scheme or table, p. 4027 - 4032 (2009/04/10)
We describe the discovery of a series of pyrazole amide EP1 receptor antagonists with good aqueous solubility and CNS penetration. In order to achieve solubility we investigated the incorporation of a basic group in the region of the molecule p
PYRAZOLE COMPOUNDS AS PROSTAGLANDIN RECEPTORS LIGANDS
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Page/Page column 162, (2008/06/13)
Compounds of formula (I) or a pharmaceutically acceptable derivative thereof: wherein Z, R1 ,R2a, R2b, R10, R11 and Rx are as defined in the specification, a process for the preparation of such compounds, pharmaceutical compositions comprising such compounds and the use of such compounds in medicine.
