91358-54-2Relevant academic research and scientific papers
PYRAZOLOTRIAZOLOPYRIMIDINE DERIVATIVES AS A2A RECEPTOR ANTAGONIST
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Paragraph 0778; 0781-0782, (2020/02/16)
Disclosed herein is a pyrazolotriazolopyrimidine derivative or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof useful as A2A receptor antagonist, and a pharmaceutical composition comprising the same. Also disclosed herein is a method of treating cancer using the pyrazolotriazolopyrimidine derivative or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof as A2A receptor antagonist.
IODOARYLATION OF ACRYLONITRILE AND ACRYLIC ESTERS WITH ARENEDIAZONIUM SALTS
Ganushchak, N. I.,Obushak, N. D.,Polishchuk, O. P.
, p. 2291 - 2295 (2007/10/02)
In the reaction of acrylic esters and acrylonitrile with arenediazonium salts in the presence of alkali-metal iodides the products from addition of the aryl radical and iodine at the double bond are formed.An effective method is proposed for the synthesis of 1-iodo-1-methoxycarbonyl(cyano)-2-arylalkanes, which enter readily into nucleophilic substitution of iodine.When boiled with an alcohol solution of alkali, they are transformed into derivatives of cinnamic acid.
