913582-10-2

Upstream product

• 2689-69-2 methyl tetrahydrothiophen-3-one-2-carboxylate 
• 17238-60-7 4-(4-chloro-phenyl)-piperazine-1-carboximidic acid amide 
• 4900-98-5 2-ethylsulfanyl-6,7-dihydro-3H-thieno[3,2-d]pyrimidin-4-one 
• 38212-33-8 4-(4-chlorophenyl) piperazine 
• 139297-07-7 2-(methylthio)-6,7-dihydrothieno[3,2-d]pyrimidin-4-ol 

Downstream Products

• 913582-13-5 4-azido-2-[4-(4-chloro-phenyl)-piperazin-1-yl]-6,7-dihydro-thieno[3,2-d]pyrimidine 
• 913582-12-4 4-chloro-2-[4-(4-chloro-phenyl)-piperazin-1-yl]-6,7-dihydro-thieno[3,2-d]pyrimidine 

Relevant academic research and scientific papers

PREPARATION OF DIHYDROTHIENO [3, 2-D] PYRIMIDINES AND INTERMEDIATES USED THEREIN

The invention relates to improved methods of preparing dihydrothienopyrimidines of formula 1, and intermediates thereof,(I) wherein X is SO or SO2, preferably SO, and wherein RA, R1, R2, R3, R4and R5 have the meanings given in the description. The methods according to this invention are more suitable for large-scale synthesis of said compounds than prior methods because the new synthetic process avoids distillation and chromatographic purification between steps and results in a higher overall yield of the desired product.

Dihydrothienopyrimidines for the Treatment of Inflammatory Diseases

The invention relates to new dihydrothienopyrimidine of formula 1, as well as pharmacologically acceptable salts, diastereomers, enantiomers, racemates, hydrates or solvates thereof, wherein X is SO or SO2, but preferably SO, and wherein R1, R2 and R3 have the meanings given in the description, and which are suitable for the treatment of respiratory or gastrointestinal complaints or diseases, inflammatory diseases of the joints, skin or eyes, diseases of the peripheral or central nervous system or cancers, as well as pharmaceutical compositions which contain these compounds.

Compounds for the treatment of inflammatory diseases

Dihydrothienopyrimidines of formula 1 and the pharmacologically acceptable salts, enantiomers, racemates, hydrates, or solvates thereof, which are suitable for the treatment of respiratory or gastrointestinal complaints or diseases, inflammatory diseases of the joints, skin, or eyes, diseases of the peripheral or central nervous system or cancers, as well as pharmaceutical compositions which contain these compounds.

DIHYDROTHIENOPYRIMIDINES FOR THE TREATMENT OF INFLAMMATORY DISEASES

The invention relates to novel dihydrothienopyrimidines of formula (1) as well as pharmaceutically acceptable salts, diastereomers, enantiomers, racemates, hydrates, or solvates thereof, which are suitable for the treatment of ailments or diseases of the respiratory tract, gastrointestinal ailments or diseases, inflammatory diseases of the joints, skin, or eyes, diseases of the peripheral or central nervous system, or cancer diseases. Also disclosed are pharmaceutical compositions containing the inventive compounds.