913582-10-2

Basic information

• Product Name: 2-[4-(4-chloro-phenyl)-piperazin-1-yl]-6,7-dihydro-thieno[3,2-d]pyrimidin-4-ol
• Synonyms: 2-[4-(4-chloro-phenyl)-piperazin-1-yl]-6,7-dihydro-thieno[3,2-d]pyrimidin-4-ol
• CAS NO: 913582-10-2
• Molecular Weight: 348.856
• Mol File: 913582-10-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-[4-(4-chloro-phenyl)-piperazin-1-yl]-6,7-dihydro-thieno[3,2-d]pyrimidin-4-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[4-(4-chloro-phenyl)-piperazin-1-yl]-6,7-dihydro-thieno[3,2-d]pyrimidin-4-ol(913582-10-2)
• EPA Substance Registry System: 2-[4-(4-chloro-phenyl)-piperazin-1-yl]-6,7-dihydro-thieno[3,2-d]pyrimidin-4-ol(913582-10-2)

Safety Data

• Hazardous Substances Data: 913582-10-2(Hazardous Substances Data)

Upstream product

• 2689-69-2 methyl tetrahydrothiophen-3-one-2-carboxylate 
• 17238-60-7 4-(4-chloro-phenyl)-piperazine-1-carboximidic acid amide 
• 38212-33-8 4-(4-chlorophenyl) piperazine 
• 139297-07-7 2-(methylthio)-6,7-dihydrothieno[3,2-d]pyrimidin-4-ol 
• 4900-98-5 2-ethylsulfanyl-6,7-dihydro-3H-thieno[3,2-d]pyrimidin-4-one 

Downstream Products

• 913582-13-5 4-azido-2-[4-(4-chloro-phenyl)-piperazin-1-yl]-6,7-dihydro-thieno[3,2-d]pyrimidine 
• 913582-12-4 4-chloro-2-[4-(4-chloro-phenyl)-piperazin-1-yl]-6,7-dihydro-thieno[3,2-d]pyrimidine 

Relevant articles and documents

PREPARATION OF DIHYDROTHIENO [3, 2-D] PYRIMIDINES AND INTERMEDIATES USED THEREIN

The invention relates to improved methods of preparing dihydrothienopyrimidines of formula 1, and intermediates thereof,(I) wherein X is SO or SO2, preferably SO, and wherein RA, R1, R2, R3, R4and R5 have the meanings given in the description. The methods according to this invention are more suitable for large-scale synthesis of said compounds than prior methods because the new synthetic process avoids distillation and chromatographic purification between steps and results in a higher overall yield of the desired product.

Compounds for the treatment of inflammatory diseases

Dihydrothienopyrimidines of formula 1 and the pharmacologically acceptable salts, enantiomers, racemates, hydrates, or solvates thereof, which are suitable for the treatment of respiratory or gastrointestinal complaints or diseases, inflammatory diseases of the joints, skin, or eyes, diseases of the peripheral or central nervous system or cancers, as well as pharmaceutical compositions which contain these compounds.