91359-40-9Relevant academic research and scientific papers
Selenium-π-Acid Catalyzed Oxidative Functionalization of Alkynes: Facile Access to Ynones and Multisubstituted Oxazoles
Liao, Lihao,Zhang, Hang,Zhao, Xiaodan
, p. 6745 - 6750 (2018/06/27)
Unprecedented selenium-catalyzed propargylic oxidation of alkynes is disclosed. Various propargylphosphonates and 3-alkynoates were efficiently converted to valuable ynones via unusual C-C triple bond migration and deselenenylation at a vinyl carbon. By the strategies of tautomerization of enamine intermediate and SN2 displacement, similar conditions were effective for the oxidative difunctionalization of ynamides to afford multisubstituted oxazoles with high regioselectivity. Mechanistic studies revealed these detailed processes.
