913641-01-7Relevant academic research and scientific papers
Aminofurazans as potent inhibitors of AKT kinase
Rouse, Meagan B.,Seefeld, Mark A.,Leber, Jack D.,McNulty, Kenneth C.,Sun, Lihui,Miller, William H.,Zhang, ShuYun,Minthorn, Elisabeth A.,Concha, Nestor O.,Choudhry, Anthony E.,Schaber, Michael D.,Heerding, Dirk A.
scheme or table, p. 1508 - 1511 (2009/11/30)
AKT inhibitors containing an imidazopyridine aminofurazan scaffold have been optimized. We have previously disclosed identification of the AKT inhibitor GSK690693, which has been evaluated in clinical trials in cancer patients. Herein we describe recent efforts focusing on investigating a distinct region of this scaffold that have afforded compounds (30 and 32) with comparable activity profiles to that of GSK690693.
INHIBITORS OF AKT ACTIVITY
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Page/Page column 112, (2008/06/13)
Invented are novel 1 H-imidazo[4,5-c]pyridin-2-yl compounds, the use of such compounds as inhibitors of protein kinase B activity and in the treatment of cancer and arthritis.
