913642-85-0

Basic information

• Product Name: (R)-N-Boc-2-morpholinecarbaldehyde
• Synonyms: (R)-N-Boc-2-morpholinecarbaldehyde;tert-Butyl (2R)-2-formylmorpholine-4-carboxylate;(R)-4-Boc-2-formyl-morpholine
• CAS NO: 913642-85-0
• Molecular Formula: C₁₀H₁₇NO₄
• Molecular Weight: 215.247
• Mol File: 913642-85-0.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 309.1°C at 760 mmHg
• Flash Point: 140.7°C
• Appearance: /
• Density: 1.18g/cm³
• Vapor Pressure: 0.000655mmHg at 25°C
• Refractive Index: 1.515
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• CAS DataBase Reference: (R)-N-Boc-2-morpholinecarbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-N-Boc-2-morpholinecarbaldehyde(913642-85-0)
• EPA Substance Registry System: (R)-N-Boc-2-morpholinecarbaldehyde(913642-85-0)

Safety Data

• Hazardous Substances Data: 913642-85-0(Hazardous Substances Data)

Usage

General Description

(R)-N-Boc-2-morpholinecarbaldehyde is a chemical compound with the molecular formula C12H21NO4. It is a white to off-white solid and is classified as an aldehyde. (R)-N-Boc-2-morpholinecarbaldehyde is commonly used in organic synthesis as a reagent in the preparation of various pharmaceuticals and other fine chemicals. It is also used as a building block in the synthesis of complex organic compounds. (R)-N-Boc-2-morpholinecarbaldehyde is known for its versatile reactivity and is an important intermediate in the pharmaceutical and industrial sectors. It is also essential for the development of new drugs and therapeutic agents.

InChI:InChI=1/C10H17NO4/c1-10(2,3)15-9(13)11-4-5-14-8(6-11)7-12/h7-8H,4-6H2,1-3H3/t8-/m1/s1

Upstream product

• 135065-76-8 tert-butyl (2S)-2-(hydroxymethyl)morpholine-4-carboxylate 
• 135065-71-3 (R)-2-hydroxymethylmorpholine-4-carboxylic acid tert-butyl ester 

Downstream Products

• 894802-06-3 tert-butyl (2S)-2-[(4-{[(3,4-dichlorophenyl)amino]-carbonyl}piperazin-1-yl)methyl]morpholine-4-carboxylate 
• 1621164-74-6 methyl (S)-2-((2-(2,6-difluoro-4-(4-methylcarbamoyl)phenyl)-7-methylimidazo[1,2-a]pyridin-3-yl)methyl)morpholine-4-carboxylate 

Relevant articles and documents

BENZIMIDAZOLE DERIVATIVES, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF

The present disclosure relates to benzimidazole derivatives, a preparation method therefor and a medical use thereof. Specifically, the present disclosure relates to a benzimidazole derivative represented by the general formula (I), a preparation method therefor, a pharmaceutical composition containing the derivative, and its use as a therapeutic agent, in particular its use for the treatment of diseases related to P2X3 activity.

PREPARATION OF A P2X3 ANTAGONIST

Described herein are two processes for the preparation of methyl (5)-2-((2-(2,6-difLuoro-4-(methylcarbamol)phenyl)-7- methylimidaz[1,2-a]pyridine-3-yl)methyl)morpholine-4-carboxylate, a P2X3 antagonist, in a stepwise manner and chemical intermediates used in the synthetic processes.

IRAK DEGRADERS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.