913645-21-3

Upstream product

• 913645-20-2 ethyl-(2-triethylsilanyloxy-ethyl)-amine 
• 16173-52-7 4-formylbenzoyl chloride 

Downstream Products

• 913645-22-4 N-ethyl-4-{(S)-[(2S,5R)-4-(3-fluoro-benzyl)-2,5-dimethyl-piperazin-1-yl]-phenyl-methyl}-N-(2-triethylsilanyloxy-ethyl)-benzamide 
• 913645-24-6 4-{(R)-((2S,5R)-4-allyl-2,5-dimethyl-piperazin-1-yl)-[3-(tetrahydro-pyran-2-yloxy)-phenyl]-methyl}-N-ethyl-N-(2-triethylsilanyloxy-ethyl)-benzamide 

Relevant academic research and scientific papers

COMPOSITIONS OF NOVEL OPIOID COMPOUNDS AND METHOD OF USE THEREOF

Diarylmethylpiperazine compounds are described, which are useful as mu and/or delta receptor opioid compounds, without central side effects. Pharmaceutical compositions containing such compounds are variously useful for peripheral or non-centrally mediated indications, including peripherally mediated and neuropathic pain, urogenital tract disorders, overactive bladder, urinary incontinence, sexual disorders, premature ejaculation, cough, lung edema, cardiac disorders, cardioprotection, gastro-intestinal disorders, diarrhea, irritable bowl syndrome, functional distention, immuno-modulation and anti-tumor activity.