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ABD-F, also known as 4-Fluoro-7-sulfamoylbenzofurazan, is a fluorescent reagent that directly links to the sulfur atom of thiols without a flexible alkyl chain. It is nonfluorescent until reacted with thiols, making it a highly reactive and specific tool for the detection and quantification of thiols in various applications.
Used in Analytical Chemistry:
ABD-F is used as a highly reactive fluorogenic reagent for the labeling of thiols for high-performance liquid chromatography (HPLC). It allows for the quantification of thiols in solution, as well as the detection of thiols separated by HPLC or thin-layer chromatography (TLC).
Used in Biochemistry:
ABD-F is used as a water-soluble, pH-dependent bifunctional fluorogenic reagent for the sensitive and specific detection of protein thiols. Its selectivity is superior to other sulfhydryl-reactive fluorophores, making it an ideal choice for studying protein thiols in various biological systems.
Used in Fluorimetric Assays:
ABD-F is used as a reagent for fluorimetric assays of thiols, providing a direct and efficient method for detecting and quantifying thiols in different samples.
General Description:
ABD-F is a light yellow solid that is highly reactive and specific for protein thiols, making it a valuable tool in various analytical and biochemical applications. Its fluorescence properties, with a maximum absorption wavelength of 385 nm and a maximum emission wavelength of 520 nm, contribute to its effectiveness in detecting low molecular thiols using high-performance liquid chromatography.

91366-65-3

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91366-65-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 91366-65-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,1,3,6 and 6 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 91366-65:
(7*9)+(6*1)+(5*3)+(4*6)+(3*6)+(2*6)+(1*5)=143
143 % 10 = 3
So 91366-65-3 is a valid CAS Registry Number.
InChI:InChI=1/C6H4FN3O3S/c7-3-1-2-4(14(8,11)12)6-5(3)9-13-10-6/h1-2H,(H2,8,11,12)

91366-65-3 Well-known Company Product Price

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  • (Code)Product description
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  • Alfa Aesar

  • (B23586)  7-Fluorobenzofurazan-4-sulfonamide, 98%   

  • 91366-65-3

  • 25mg

  • 2058.0CNY

  • Detail

  • Alfa Aesar

  • (B23586)  7-Fluorobenzofurazan-4-sulfonamide, 98%   

  • 91366-65-3

  • 100mg

  • 6110.0CNY

  • Detail

  • Sigma

  • (F3639)  4-Fluoro-7-sulfamoylbenzofurazan  

  • 91366-65-3

  • F3639-10MG

  • 3,722.94CNY

  • Detail

  • Sigma

  • (F3639)  4-Fluoro-7-sulfamoylbenzofurazan  

  • 91366-65-3

  • F3639-50MG

  • 12,823.20CNY

  • Detail

91366-65-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-(Aminosulfonyl)-7-fluoro-2,1,3-benzoxadiazole

1.2 Other means of identification

Product number -
Other names 7-fluoro-2,1,3-benzoxadiazole-4-sulfonamide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:91366-65-3 SDS

91366-65-3Downstream Products

91366-65-3Relevant academic research and scientific papers

New Fluorogenic Reagent Having Halogenobenzofurazan Structure for Thiols: 4-(Aminosulfonyl)-7-fluoro-2,1,3-benzoxadiazole

Toyo'oka, Toshimasa,Imai, Kazuhiro

, p. 2461 - 2464 (1984)

4-(Aminosulfonyl)-7-fluoro-2,1,3-benzoxadiazole (ABD-F) has been synthesized as a new fluorogenic reagent for thiols.Its reaction rate to homocysteine is over 30 times faster than that with ammonium 7-fluoro-2,1,3-benzoxadiazole-4-sulfonate (SBD-F).The fluorogenic reaction to thiol was completed quantitatively in 5 min at 50 deg C and pH 8.0.Alanine, proline, and cystine did not react under the same conditions.The fluorescence intensity of the fluorophor was pH dependent with the highest at pH 2.The ABD-thiols obtained by the prelabeling technique were separated and detected by reversed-phase HPLC.The detection limits (S/N = 3) for cysteine, glutathione, N-acetylcysteine, homocysteine, and cysteamine were 0.6, 0.4, 1.9, 0.5, and 0.5 pmol, respectively.

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