913701-50-5Relevant academic research and scientific papers
Second generation β-elemene nitric oxide derivatives with reasonable linkers: potential hybrids against malignant brain glioma
Bai, Renren,Zhu, Junlong,Bai, Ziqiang,Mao, Qing,Zhang, Yingqian,Hui, Zi,Luo, Xinyu,Ye, Xiang-Yang,Xie, Tian
, p. 379 - 385 (2022/01/20)
Elemene is a second-line broad-spectrum anti-tumour drug that has been used in China for more than two decades. However, its main anti-tumour ingredient, β-elemene, has disadvantages, including excessive lipophilicity and relatively weak anti-tumour effic
Beta-elemene derivative containing dihydropyridine structure, and preparation method and purpose thereof
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Paragraph 0051; 0052, (2017/10/13)
The invention relates to the field of new medicine research and development and tumor therapy, in particular to a novel beta-elemene derivative containing a dihydropyridine structure, particularly a derivative directly or indirectly introducing the brain-targeted dihydropyridine structure through a connecting arm in a beta-elemene 13 bit. The invention also discloses a preparation method of the beta-elemene derivative with the brain-targeted function, and a purpose of the novel derivative for treating gliomas.
