913722-22-2

Upstream product

• 121467-56-9 (2R,4aR,6S,8aR)-6-Methoxy-7,7-dimethyl-2-phenyl-tetrahydro-pyrano[3,2-d][1,3]dioxin-8-one 
• 913722-18-6 imidazole-1-carbothioic acid O-[2-(tert-butyl-diphenyl-silanyloxymethyl)-6-methoxy-5,5-dimethyl-4-oxo-tetrahydro-pyran-3-yl] ester 
• 913722-17-5 (2S,5R,6R)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-5-hydroxy-2-methoxy-3,3-dimethyl-tetrahydro-pyran-4-one 
• 913722-19-7 (2S,6S)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-2-methoxy-3,3-dimethyl-tetrahydro-pyran-4-one 
• 913722-16-4 (2S,5R,6R)-5-Hydroxy-6-hydroxymethyl-2-methoxy-3,3-dimethyl-tetrahydro-pyran-4-one 
• 913722-20-0 (2S,4S,6S)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-2-methoxy-3,3-dimethyl-tetrahydro-pyran-4-ol 
• 89238-99-3 O-(4-methoxybenzyl)-trichloroacetimidate 

Downstream Products

• 127861-24-9 3-{(4S,6R)-6-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-3-methyl-butan-2-one 
• 913722-29-9 tert-Butyl-{2-[(4R,6S)-6-(1-[1,3]dithian-2-yl-1-methyl-ethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-ethoxy}-diphenyl-silane 
• 913722-28-8 (3R,5S)-1-(tert-Butyl-diphenyl-silanyloxy)-6-[1,3]dithian-2-yl-6-methyl-heptane-3,5-diol 
• 130199-54-1 2-{(4S,6R)-6-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-2-methyl-propionaldehyde 
• 913722-26-6 2-[(2R,4S,6S)-6-Methoxy-4-(4-methoxy-benzyloxy)-5,5-dimethyl-tetrahydro-pyran-2-yl]-ethanol 
• 913722-25-5 (2S,4S,6S)-2-Methoxy-4-(4-methoxy-benzyloxy)-3,3-dimethyl-6-vinyl-tetrahydro-pyran 
• 913722-24-4 (2S,4S,6S)-6-Methoxy-4-(4-methoxy-benzyloxy)-5,5-dimethyl-tetrahydro-pyran-2-carbaldehyde 
• 913722-23-3 [(2S,4S,6S)-6-Methoxy-4-(4-methoxy-benzyloxy)-5,5-dimethyl-tetrahydro-pyran-2-yl]-methanol 

Relevant academic research and scientific papers

Enantioselective formal total synthesis of the antitumor macrolide bryostatin 7

A new enantioselective synthesis of Masamune's AB fragment (1) for bryostatin 7 is described. Key steps in the new route include a Meerwein-Ponndorf-Verley reduction to set the 0(7) stereocenter and an alkylative union between the dithiane 6 and iodide 5 to construct the C(9)-C(10) bond. Because we have previously published a synthesis of Masamune's C-ring phenyl sulfone 2, our new route to 1 constitutes a formal total synthesis of bryostatin 7; it also corrects the previously reported spectral data for 1 in CDCl3.