91374-24-2

Basic information

• Product Name: Ethyl 3-[2-[2-(dipropylamino)ethyl]-6-nitrophenyl]-2-oxopropanoate
• Synonyms: 2-[2-(Dipropylamino)ethyl]-6-nitro-oxobenzene propanoic acid ethyl ester;Ropinirole Intermediate 3;2-[2-(Dipropylamino)ethyl]-6-nitro-alpha-oxobenzenepropanoic acid ethyl ester;Ethyl 3-[2-[2-(dipropylamino)ethyl]-6-nitrophenyl]-2-oxopropanoate
• CAS NO: 91374-24-2
• Molecular Formula: C₁₉H₂₈N₂O₅
• Molecular Weight: 364.44
• Mol File: 91374-24-2.mol

Chemical Properties

• Boiling Point: 484.2°C at 760 mmHg
• Flash Point: 246.6°C
• Appearance: /
• Density: 1.127
• Vapor Pressure: 1.58E-09mmHg at 25°C
• Refractive Index: 1.525
• PKA: 9.24±0.50(Predicted)
• CAS DataBase Reference: Ethyl 3-[2-[2-(dipropylamino)ethyl]-6-nitrophenyl]-2-oxopropanoate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 3-[2-[2-(dipropylamino)ethyl]-6-nitrophenyl]-2-oxopropanoate(91374-24-2)
• EPA Substance Registry System: Ethyl 3-[2-[2-(dipropylamino)ethyl]-6-nitrophenyl]-2-oxopropanoate(91374-24-2)

Safety Data

• Hazardous Substances Data: 91374-24-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Ethyl 3-[2-[2-(dipropylamino)ethyl]-6-nitrophenyl]-2-oxopropanoate is used as an impurity in the production of Ropinirol, an antiparkinsonian agent. It is important to monitor and control the levels of this impurity to ensure the safety and efficacy of the drug.

InChI:InChI=1/C19H28N2O5/c1-4-11-20(12-5-2)13-10-15-8-7-9-17(21(24)25)16(15)14-18(22)19(23)26-6-3/h7-9H,4-6,10-14H2,1-3H3

Upstream product

• 920986-68-1 N-[2-(2-methyl-3-nitrophenyl)ethyl]-N-propylpropan-1-amine hydrochloride 
• 95-92-1 oxalic acid diethyl ester 
• 91374-23-1 1-(2-dipropylaminoethyl)-2-methyl-3-nitrobenzene 

Downstream Products

• 91374-25-3 <2-nitro-6-<2-(N,N-di-n-propylamino)ethyl>phenyl>acetic acid hydrochloride 

Relevant articles and documents

PROCESS FOR THE PREPARATION OF ROPINIROLE AND SALTS THEREOF

The present invention relates to an improved process for the preparation of Ropinirole and pharmaceutical acceptable salts or derivatives thereof, in particular to a process for large scale production of Ropinirole and salts thereof in high yield and high purity and pharmaceutical preparations containing said compounds.

PROCESS FOR THE PREPARATION OF INDOLONE DERIVATIVE

A process for the preparation of 4-[2-(Di-n-propylamino) ethyl]-2,3-dihydro-1 H-indol-2-one of formula (I) and its pharmaceutically acceptable salts, solvates Formaula I involving new intermediates of compound of formula (A) and (B) wherein R represents (i) a halogen atom selected from fluorine, chlorine atom, bromine atom and iodine atom; (ii) lower alkanesulfonyloxy group selected from methanesulfonyloxy, ethanesulfonyloxy, isopropanesulfonyloxy, propanesulfonyloxy, butanesulfonyloxy, tert-butanesulfonyloxy, pentanesulfonyloxy, hexanesulfonyloxy; (iii) substituted or unsubstantiated arylsulfonyloxy group selected from phenylsulfonyloxy, 4-methylphenylsulfonyloxy, 2-methylphenylsulfonyloxy, 4- nitrophenylsulfonyloxy, 4- methoxyphenylsulfonyloxy, 3-chlorophenylsulfonyloxy; (iv) arylalkylsulfonyloxy group selected from benzylsulfonyloxy, 2- phenylethylsulfonyloxy, 4-phenylbutylsulfonyloxy, 4- methylbenzylsulfonyloxy, 2- methylbenzylsulfonyloxy, 4- nitrobenzylsulfonyloxy, 4-methoxybenzylsulfonyloxy, 3- chlorobenzylsulfonyloxy.

Pharmaceutical methods using 4-aminoalkyl-2(3H)-indolones

A series of pharmaceutical compositions which contain 4-aminoalkyl-2(3H)-indolones has been demonstrated to have D2 -agonist activity useful for treating congestive heart failure and hypertension. A representative ingredient of the compositions is 4-di-n-propylaminoethyl-2(3H)-indolone or a salt thereof.

4-Aminoalkyl-2(3H)-indolones

A series of new chemical compounds which are 4-aminoalkyl-2(3H)-indolones has been demonstrated to be D2 -agonists useful for treating hypertension. A representative compound of the series is 4-di-n-propylaminoethyl-2(3H)-indolone.