913814-06-9Relevant academic research and scientific papers
Design, synthesis, inhibitory activity, and binding mode study of novel DNA methyltransferase 1 inhibitors
Suzuki, Takayoshi,Tanaka, Rikako,Hamada, Shohei,Nakagawa, Hidehiko,Miyata, Naoki
, p. 1124 - 1127 (2010)
To identify novel non-nucleoside DNA methyltransferase (DNMT) inhibitors, we designed and synthesized a series of maleimide derivatives. Among this series, compounds 5-8 were found to be more potent DNMT1 inhibitors than RG108, a DNMT1 inhibitor reported previously by Siedlecki et al. The binding mode analysis of compound 5 is also reported.
