913814-30-9

Usage

Uses

Used in Pharmaceutical Industry:
Azetidine, 1-(diphenylMethyl)-3-phenylis used as a building block in organic synthesis for the development of new pharmaceutical compounds. Its unique structure and promising biological activities, such as anticancer and antiviral properties, make it a valuable target for further research and drug development.
Used in Organic Synthesis:
Azetidine, 1-(diphenylMethyl)-3-phenylis used as a key intermediate in the synthesis of various organic compounds. Its five-membered ring structure and the presence of phenyl and diphenylmethyl groups provide a versatile platform for the creation of new molecules with potential applications in various industries, including pharmaceuticals, agrochemicals, and materials science.

Upstream product

• 91-00-9 Benzhydrylamine 
• 1570-95-2 2-phenylpropane-1, 3-diol 
• 125735-40-2 1-benzhydryl-3-iodoazetidine 
• 100-58-3 phenylmagnesium bromide 
• 18621-17-5 1-(diphenylmethyl)-3-hydroxyazetidine 
• 33301-41-6 1-benzhydryl-3-azetidinyl methanesulfonate 

Downstream Products

• 4363-13-7 phenyl-3-azetidine 

Relevant academic research and scientific papers

Counterion-Induced Asymmetric Control in Ring-Opening of Azetidiniums: Facile Access to Chiral Amines

Counterion-induced stereocontrol is a powerful tool in organic synthesis. However, such enantiocontrol on tetrahedral ammonium cations remains challenging. Described here is the first example of using chiral anion phase-transfer catalysis to achieve intermolecular ring-opening of azetidiniums with excellent enantioselectivity (up to 97 % ee). Precise control over the formation and reaction of the chiral ion pair as well as inhibition of the background reaction by the biphasic system is key to the success of the reaction.

Iron catalysed cross-couplings of azetidines-application to the formal synthesis of a pharmacologically active molecule

A protocol for the coupling of 3-iodoazetidines with Grignard reagents in the presence of an iron catalyst has been developed. A variety of aryl, heteroaryl, vinyl and alkyl Grignards were shown to participate in the coupling process to give the products in good to excellent yields. Furthermore, a short formal synthesis towards a pharmacologically active molecule was shown. This journal is

6-N-Linked Heterocycle-Substituted 2,3,4,5-Tetrahydro-1H-Benzo[d]Azepines as 5-Ht2c Receptor Agonists

The present invention provides 6-substituted 2,3,4,5-tetrahydro-1H-benzo[d]azepines of Formula I as selective 5-HT2C receptor agonists for the treatment of 5-HT2C associated disorders including obesity, obsessive/compulsive disorder, depression, and anxiety: Formula (I) where: R6 is selected from the group consisting of (a, b, c, d, e) and other substituents are as defined in the specification.

A one-pot preparation of 1,3-disubstituted azetidines

(Chemical Equation Presented) A straightforward synthesis of 1,3-disubstituted azetidines has been accomplished via the alkylation of a primary amine with the bis-triflate of a 2-substituted-1,3-propanediol species. This transformation is carried out in o