91384-07-5Relevant articles and documents
Synthesis of New N-alkyl-5-formyl-2-methylpyrrole Derivatives from Glucosamine
Tao, Tao,Zhao, Hua Xin,Ji, Xiao Ming,Lai, Miao,Zhao, Ming Qin
, p. 943 - 945 (2018)
Glucosamine hydrochloride 1 was treated with 1,3-dicarbonyl compounds to obtain 2-methyl-5-(1,2,3,4-tetrahydroxy-butyl) pyrrole 2a and 2b, respectively. Under the role of NaIO4, 2a and 2b were successfully transformed into the related 5-formal pyrrole derivative 3a and 3b, respectively. Compounds 4a–4d and 5a–5e were obtained by reacting 3a and 3b with chlorinated hydrocarbons by alkylation reactions, respectively. The structures of all new products were confirmed by IR, NMR, and HRMS spectra.