91396-94-0Relevant academic research and scientific papers
On the Metalation of 4-Substituted Pyridazines
Turck, Alain,Ple, Nelly,Mojovic, Ljubica,Ndzi, Bruno,Queguiner, Guy,et al.
, p. 841 - 846 (2007/10/02)
A series of new pyridazines bearing ortho-directing groups at C-4 (protected/activated amino or carboxylic acid functionalities) was prepared and their metalation with lithium 2,2,6,6-tetramethylpiperidine was studied.Reactions of the ortho-lithiated species thus obtained with aldehydes as electrophiles opens an access to 4,5-disubstituted pyridazines 3, 4, 14, and 15.
