913962-60-4

Basic information

• Product Name: (1'S,2'S,3R)-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-N,3,4-trimethylpentanamide
• Synonyms: (1'S,2'S,3R)-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-N,3,4-trimethylpentanamide
• CAS NO: 913962-60-4
• Molecular Weight: 277.407
• Mol File: 913962-60-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (1'S,2'S,3R)-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-N,3,4-trimethylpentanamide(CAS DataBase Reference)
• NIST Chemistry Reference: (1'S,2'S,3R)-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-N,3,4-trimethylpentanamide(913962-60-4)
• EPA Substance Registry System: (1'S,2'S,3R)-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-N,3,4-trimethylpentanamide(913962-60-4)

Safety Data

• Hazardous Substances Data: 913962-60-4(Hazardous Substances Data)

Upstream product

• 1888-75-1 isopropyllithium 
• 678991-32-7 E-(+)-(1'S,2'S)-N-methyl-N-(2'-phenyl-2'-hydroxy-1'-methylethyl)but-2-enamide 

Relevant articles and documents

(S,S)-(+)-pseudoephedrine as chiral auxiliary in asymmetric conjugate addition and tandem conjugate addition/α-alkylation reactions

(Chemical Equation Presented) Organolithium reagents undergo highly regio- and diastereoselective 1,4-addition to (S,S)-(+)-pseudoephedrine enamides furnishing the corresponding β-alkyl-substituted adducts in excellent yields and diastereoselectivities. In addition, the intermediate lithium enolates generated after the conjugate addition step undergo a highly diastereoselective alkylation reaction, furnishing α,β-dialkyl- substituted amides in high yields. The obtained adducts have been converted into chiral nonracemic β-alkyl- and α,β-dialkyl-substituted carboxylic acids and γ-alkyl- and β,γ-dialkyl-substituted alcohols using very simple and high-yielding procedures.