913981-93-8Relevant articles and documents
Identification of selective, nonpeptidic nitrile inhibitors of cathepsin S using the substrate activity screening method
Patterson, Andrew W.,Wood, Warren J. L.,Hornsby, Michael,Lesley, Scott,Spraggon, Glen,Ellman, Jonathan A.
, p. 6298 - 6307 (2006)
The substrate activity screening method, a substrate-based fragment identification and optimization method for the development of enzyme inhibitors, was previously applied to cathepsin S to obtain low nanomolar 1,4-disubstituted-1,2,3-triazole-based aldeh