914076-75-8Relevant academic research and scientific papers
Expanding the scope of atropisomeric monodentate P-donor ligands in asymmetric catalysis: Hydrogen-transfer reduction of α,β-unsaturated acid derivatives by rhodium/Ph-binepine catalysts
Alberico, Elisabetta,Nieddu, Ilenia,Taras, Rossana,Gladiali, Serafino
, p. 1716 - 1729 (2007/10/03)
A range of α,β-unsaturated acids and esters have been selectively reduced to the corresponding saturated acid derivatives by hydrogen transfer. As the reducing agent, formic acid was used in the presence of Rh 1 complexes formed with the powerful chiral ligand Ph-binepine (1), an axially chiral binaphthalene-type monodentate P-donor ligand. Very high stereoselectivities (up to 97% ee) were obtained in the case of itaconic acid (2a).
