914090-96-3Relevant academic research and scientific papers
Rapid access to novel 1,2,3-triazolo-heterocyclic scaffolds via tandem knoevenagel condensation/azide-alkyne 1,3-dipolar cycloaddition reaction in one pot
Maurya, Ram Awatar,Adiyala, Praveen Reddy,Chandrasekhar,Reddy, Chada Narsimha,Kapure, Jeevak Sopanrao,Kamal, Ahmed
, p. 466 - 477 (2014)
An operationally simple, one-pot, two-step cascade method has been developed to afford biologically important fused 1,2,3-triazolo-heterocyclic scaffolds from 2-alkynyl aryl(heteroaryl) aldehydes and phenacyl azides. This unique atom economical transformation engages four reactive centers (aldehyde, alkyne, active methylene, and azide) under metal-free catalysis.
A α - azido carbonyl compound and its preparation method (by machine translation)
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Paragraph 0096; 0097; 0098; 0099; 0100; 0101; 0102-0106, (2017/09/02)
The invention relates to a kind of α - azido carbonyl compound and its preparation method, in organic solvent, in order to end alkyne with trimethyl silicon nitrine as reaction raw material, in the copper catalysts and the persulfate oxidizing agent under the action of the common promotion, through the alkyne of double-functionalized α - azido obtained by reaction of a carbonyl compound. Azido free radical oxidation using air as the oxidizing agent in the terminal played a key role in the reaction process. The method substrate range widely, room temperature operation, mild reaction conditions, after treatment is simple and the yield of the product and high purity, is α - azido carbonyl compound has opened up a new synthetic route and method, and has good application potential and research value. (by machine translation)
Synthesis and biological evaluation of 5-substituted and 4,5-disubstituted-2-arylamino oxazole TRPV1 antagonists
Perner, Richard J.,Koenig, John R.,Didomenico, Stanley,Gomtsyan, Arthur,Schmidt, Robert G.,Lee, Chih-Hung,Hsu, Margaret C.,McDonald, Heath A.,Gauvin, Donna M.,Joshi, Shailen,Turner, Teresa M.,Reilly, Regina M.,Kym, Philip R.,Kort, Michael E.
supporting information; experimental part, p. 4821 - 4829 (2010/08/06)
The synthesis and structure-activity relationships of a series of 5-monosubstituted and 4,5-disubstituted 2-arylaminooxazoles as novel antagonists of the transient receptor potential vanilloid 1 (TRPV1) receptor are described. The 7-hydroxy group of the t
