914101-01-2Relevant academic research and scientific papers
Rational design of a topical androgen receptor antagonist for the suppression of sebum production with properties suitable for follicular delivery
Mitchell, Lorna H.,Johnson, Theodore R.,Lu, Guang Wei,Du, Daniel,Datta, Kaushik,Grzemski, Felicity,Shanmugasundaram, Veerabahu,Spence, Julie,Wade, Kim,Wang, Zhi,Sun, Kevin,Lin, Kristin,Hu, Lain-Yen,Sexton, Karen,Raheja, Neil,Kostlan, Catherine,Pocalyko, David
supporting information; experimental part, p. 4422 - 4427 (2010/09/04)
A novel nonsteroidal androgen receptor antagonist, (R)-4-(1-benzyl-4,4- dimethyl-2-oxopyrrolidin-3-yloxy)-2-(trifluoromethyl)benzonitrile (1), for the topical control of sebum production is reported. This compound, which is potent, selective, and efficacious in the clinically validated golden Syrian hamster ear animal model, was designed to be delivered to the pilosebaceous unit, the site of action, preferentially by the follicular route.
