91417-83-3Relevant academic research and scientific papers
ACETALS OF LACTAMS AND ACID AMIDES. 50. 1-CYANOMETHYLPYRROLID-2-ONE DIETHYLACETAL IN THE SYNTHESIS OF DERIVATIVES OF PYRROLOPYRROLES
Kadushkin, A. V.,Stezhko, T. V.,Solov'eva, N. P.,Granik, V. G.
, p. 1297 - 1301 (2007/10/02)
We have synthesized a series of enamines - derivatives of 1-cyanomethyl-2-methylenepyrrolidine - by reaction of 1-cyanomethylpyrrolid-2-one diethylacetal with compounds having a reactive methylene link.The enamines undergo a Thorpe-Ziegler cyclization in the presence of bases with the formation of pyrrolopyrrole derivatives.The configuration of the enamines obtained were studied using PMR spectroscopy.
