91418-45-0Relevant academic research and scientific papers
Role of Knoevenagel condensate pyrazolone derivative Schiff base ligated transition metal complexes in biological assay and cytotoxic efficacy
Paulpandiyan, Rajakkani,Arunadevi, Alagarraj,Raman, Natarajan
, (2017)
A new bioessential Knoevenagel condensate Schiff base ligand (L) was synthesized by the reaction of 3-(4-hydroxy-3-methoxybenzyl)pentane-2,4-dione and 4-aminoantipyrine. The ligand forms monomeric divalent transition metal complexes (1–4) which were chara
Microwave Oriented Solid Support Synthesis of Novel 5,6-Disubstituted-1,2,4-Triazolopyrimidines as Antifungal Agents
Bala, Anju,Gumber, Khushbu,Sidhu, Anjali,Sidhu, Navjot Kaur
, p. 39 - 46 (2021/06/12)
Microwave oriented, basic solid support assisted, two-step reaction of aryl aldehyde, active methylene compounds, and 3-amino-1,2,4-triazole yielded 5,6-disubstituted-1,2,4-triazolopyrimidines in excellent yield without side products, in short reaction time. The preliminary in vitro antifungal evaluation of the compounds indicated the promising antifungal potential of the synthesized compounds against most of the test fungi using standard fungicides as a positive control. The in silico analysis of the synthesized molecules favors the results of in vitro analysis.
4 - arylmethyl curcumin analogs as Hsp90 inhibitors
-
Paragraph 0036, (2017/08/25)
The invention discloses application of a 4-arylmethyl curcumin analogues serving as an Hsp90 inhibitor. The 4-arylmethyl curcumin analog in serving as Hsp90 inhibitor has a structural formula as shown in the specification, wherein Ar is aromatic ring or a
Biological evaluation and molecular docking studies of new curcuminoid derivatives: Synthesis and characterization
Banuppriya, Govindharasu,Sribalan, Rajendran,Padmini, Vediappen,Shanmugaiah, Vellasamy
supporting information, p. 1655 - 1659 (2016/07/27)
In the present study, three series of dimethylamino curcuminoids viz. 4-phenylaminomethyl curcumin (3a–d), arylidene curcumin (3e) and pyrazole curcumin (3f–i) derivatives have been synthesized and studied for their in vitro anti-inflammatory, antioxidant
Synthesis and evaluation of 4-arylmethyl curcumin analgues as potent Hsp90 inhibitors
Liu, Yang,Ye, Min,Wu, Qundan,Wu, Lixian,Xu, Jianhua
, p. 993 - 999 (2014/10/15)
Hsp90 is a potential target for the treatment of cancer. Curcumin is a natural product used to prevent and treat cancer. 4-(4-Hydroxy-3-methoxybenzyl) curcumin (C086), a 4-arylmethyl curcumin analogue, showed lead-like properties. Western blot analyses an
Laccase-catalyzed oxidative phenolic coupling of vanillidene derivatives
Constantin, Mihaela-Anca,Conrad, Juergen,Beifuss, Uwe
supporting information, p. 2375 - 2379 (2013/02/21)
The laccase-catalyzed oxidative phenolic coupling of vanillidene derivatives using aerial oxygen as the oxidant has been developed. Depending on the substitution pattern of the vanillidene double bond of the substrate, either dilactones, dihydrobenzo[b]furans or biphenyls are formed.
A facile synthesis of trisubstituted alkenes from β-diketones and aldehydes with AlCl3 as catalyst
Li, Zheng-Nan,Chen, Xiao-Liang,Fu, Yu-Jie,Wang, Wei,Luo, Meng
experimental part, p. 25 - 35 (2012/05/20)
Preparation of trisubstituted alkenes from low-activity β-diketones and aldehydes with aluminum chloride as catalyst has been studied. The frequently used catalyst AlCl3 is used for the first time to promote this condensation. The procedure is a convenient, low toxicity, and highly efficient method for industrial synthesis of trisubstituted alkenes in high yield. Springer Science+Business Media B.V. 2011.
New fluorescent trans-dihydrofluoren-3-ones from aldol-Robinson annulation-regioselective addition involved one-pot reaction
Huo, Yingpeng,Qiu, Xu,Shao, Weiyan,Huang, Jianing,Yu, Yanjun,Zuo, Yinglin,An, Linkun,Du, Jun,Bu, Xianzhang
supporting information; experimental part, p. 5048 - 5052 (2010/12/25)
An unexpected discovery of new trans-4-acetyl-1,9-dimethyl-4,4a-dihydro-3H- fluoren-3-ones from one pot reactions of benzaldehydes and acetylacetone is described. The synthetic mechanism and stereochemistry were discussed. These new derivatives exhibit go
Synthesis of some new unsymmetrically substituted 1,4-dihydropyridines
Memarian, Hamid R.,Abdoli-Senejani, Masumeh,D?pp, Dietrich
, p. 50 - 56 (2008/02/10)
A series of some new 3,5-unsymmetrically substituted 1,4-dihydropyridines have been synthesized, which have ethoxycarbonyl and acetyl groups on 3- and 5-positions, respectively. A three-step procedure has been examined to increase the yield of the desired products, by suppressing the formation of the symmetrically substituted 3,5-diacetyl-1,4-dihydropyridines and 3,5-diethoxycarbonyl-1,4-dihydropyridines.
